Publications

2021

Zhao, F., S. Wang, Y. Li, J. Wang, Y. Wang, C. Zhang, Y. Li, L. Huang, Y. Yu, B. Yu, J. Zheng, I. Pessah, Z. Cao (2021) Surfactant cocamide monoethanolamide causes eye irritation by activating nociceptor TRPV1, British Journal of Pharmacology, (in press)

Liu, C., R. Reese, S. Vu, L. Rougé, S. Shields, H. Chen, Y. Shi, T. Chernov-Rogan, K. Johnson, D.M.Z. Greiner, P.B. Kohli, D. Hackos, S. Kakiuchi-Kiyota, B. Brillantes, C. Tam, T. Li, J. Wang, S. Magnuson, M. Volgraf, J. Payandeh, J. Zheng, A. Rohou and J. Chen (2021) A non-covalent ligand reveals biased agonism at the TRPA1 ion channel, Neuron, 109(2):273-284.e4. doi: 10.1016/j.neuron.2020.10.014.

2020

Vu, S., V. Singh, H. Wulff, V. Yarov-Yarovoy, J. Zheng (2020) New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket, eLife, 9:e62039. DOI: https://doi.org/10.7554/eLife.62039

Yang, F.¶, L. Xu, B.H. Lee, X. Xiao, V. Yarov-Yarovoy, J. Zheng¶ (2020) An unorthodox mechanism underlying voltage sensitivity of TRPV1 ion channel, Advanced Science, 2000575. DOI: 10.1002/advs.202000575

Du, G., Y. Tian, Z. Yao, S. Vu, J. Zheng, L. Chai, K. Wang, S. Yang (2020) A specialized pore turret in the mammalian cation channel TRPV1 is responsible for distinct and species-specific heat activation thresholds, Journal of Biological Chemistry, 295(28):9641-9649; DOI: 10.1074/jbc.RA120.013037

Zhu, A., A. Aierken, Z. Yao, S. Vu, Y. Tian¶, J. Zheng¶, S. Yang¶, F. Yang¶ (2020) A centipede toxin causes rapid desensitization of nociceptor TRPV1 ion channel, Toxicon, 178:41-49; DOI:10.1016/j.toxicon.2020.02.016

2019

Yao, Z., P.M. Kamau, Y. Han, J. Hu, A. Luo, L. Luo¶, J. Zheng¶, Y. Tian¶, R. Lai¶ (2019) The Latoia consocia caterpillar induces pain by targeting nociceptive ion channel TRPV1, Toxins, 11: 695; DOI:10.3390/toxins11120695
6. Dong, Y., Y. Yin, S. Vu, F. Yang, V. Yarov-Yarovoy, Y. Tian¶, J. Zheng¶ (2019) A distinct structural mechanism underlies TRPV1 activation by piperine, Biochemical and Biophysical Research Communications, 516: 365-372 DOI: 10.1016/j.bbrc.2019.06.039

Yin, Y., Y. Dong, S. Vu, F. Yang, V. Yarov-Yarovoy, Y. Tian¶, J. Zheng¶ (2019) Structural Mechanism Underlying TRPV1 Activation by Pungent Compounds in Gingers, British Journal of Pharmacology, 176: 3364–3377. DOI: 10.1111/bph.14766

Luo, L., Y. Wang, B. Li, L. Xu, P.M. Kamau, J. Zheng, F. Yang¶, S. Yang¶, R. Lai¶ (2019) Molecular Basis for Heat Desensitization of TRPV1 Ion Channels, Nature Communications, 10:2134 (¶ corresponding authors)

2018

Wang, H., Z. Xu, B.H. Lee, S. Vu, L. Hu, M. Lee, D. Bu, X. Cao, S. Hwang, Y. Yang, J. Zheng, Z. Lin¶ (2018) Gain-of-function mutations in TRPM4 activation gate cause progressive symmetric erythrokeratoderma, Journal of Investigative Dermatology, 139:1089-1097 (¶ corresponding authors)

Yang, F., X. Xiao, B.H. Lee, S. Vu, W. Yang, V. Yarov-Yarovoy, J. Zheng (2018) The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel, Nature Communications,9:2879 | DOI: 10.1038/s41467-018-05339-6

Han, Y., B. Li, T. Yin, C. Xu, R. Ombati, L. Luo, Y. Xia, L. Xu, J. Zheng, Y. Zhang, F. Yang, G. Wang, S. Yang, R. Lai (2018) Molecular mechanism of tree shrew’s insensitivity to pungency, PLoS Biology, 16(7): e2004921.

2017

Yang, S., F. Yang, B. Zhang, B.H. Lee, B. Li, L. Luo, J. Zheng¶, and R. Lai¶ (2017) A novel bi-modal activation mechanism underlies scorpion toxin induced pain, Science Advances, 3: e1700810 (¶ corresponding authors)

*** The paper by Yang, S., F. Yang, et al.(2017) is highlighted by Discover Magazine.

Yang, F., and J. Zheng (2017) Understand spiciness: mechanism of TRPV1 channel activation by capsaicin, Protein & Cell, 8(3):169-177

2016

He, X. C. Shen, Q. Lu, J. Li, Y. Wei, L. He, R. Bai, J. Zheng, N. Luan, Z. Zhang, M. Rong, R. Lai (2016) Prokineticin 2 Plays a Pivotal Role in Psoriasis, EBioMedicine, DOI: 10.1016/j.ebiom.2016.10.022

Ma, L., F. Yang, S. Vu, and J. Zheng (2016) Exploring functional roles of TRPV1 intracellular domains with unstructured peptide-insertion screening, Scientific Reports, 6:33827, DOI: 10.1038/srep33827

Kim, S., D. Barry, X.Y. Liu, S. Yin, A. Munanairi, Q.T. Meng, W. Cheng, P. Mo, L. Wan, S.B. Liu, K. Ratnayake, Z. Q. Zhao, N. Gautam, J. Zheng, W.K.A. Karunarathne, and Z. F. Chen (2016) Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations, Science Signaling, 9(437): ra71

	Yang, F., S. Vu, V. Yarov-Yarovoy, and J. Zheng (2016) Rational design and validation of a vanilloid-sensitive TRPV2 ion channel, Proceedings of the National Academy of Sciences, USA, E3657–E3666

2015

Simonov, A.N., J.K. Holien, J.C.I. Yeung, A.D. Nguyen, C.J. Corbin, J. Zheng, V.L. Kuznetsov, R.J. Auchus, A.J. Conley, A.M. Bond, M.W. Parker, R.J. Rodgers, L.L. Martin (2015) Mechanistic scrutiny identifies a kinetic role for cytochrome b5 regulation of human cytochrome P450c17, PLoS One, 10(11): e0141252

Yang, S., F. Yang, N. Wei, J. Hong, B. Li, L. Luo, M. Rong, V. Yarov-Yarovoy, J. Zheng¶, K.W. Wang¶, R. Lai¶ (2015) A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1, Nature Communication, 6:8297 (¶ corresponding authors)

Lee, B.H., and J. Zheng (2015) Proton block of proton-activated TRPV1 current, Journal of General Physiology, 146(2):147-159

Yang, F., X. Xiao, W. Cheng, W. Yang, P. Yu, Z. Song, V. Yarov-Yarovoy, J. Zheng (2015), Structural mechanism underlying capsaicin binding and activation of nociceptive TRPV1 ion channel, Nature Chemical Biology, 11:518–524

  Jie Zheng and Matthew C. Trudeau (editors), Handbook of Ion Channels, CRC Press

** Review by Richard Aldrich (2015) A new standart: a review of Handbook of Ion Channels, Journal of General Physiology, 146(2):119-121
** Review by David R. Harder (2015) Physiologist, 58(4):205-208
** Review by Bingcai Guan, Zuan Zhou, Hailin Zhang (2015) Acta Physiologica Sinica, 67(5)

Clifton, H.L., B. Inceoglu, L. Ma, J. Zheng, S. Schaefer (2015) TRPV1 Channels are Involved in Niacin-induced Cutaneous Vasodilation in Mice, Journal of Cardiovascular Pharmacology, 65(2):184-191

Ma, L., B.H. Lee, H. Clifton, S. Schaefer, and Jie Zheng (2015) Nicotinic acid is a common regulator of heat-sensing TRPV1-4 ion channels, Scientific Reports, 5:8906; DOI:10.1038/srep08906

Zheng, J., X. Zeng, and S. Wang (2015) Calcium as cellular messenger, Science China Life Sciences, 58(1):1-5

2014

Zheng, J. and L. Ma (2014) Structure and Function of the ThermoTRP Channel Pore, in L. D. Islas, & F. Qin (Eds.), Thermal Sensors, 233-257

Tang, Y.Q., J.H. Zhou, F. Yang, J. Zheng, and K.W. Wang (2014) The tetramerization domain potentiates Kv4 channel function by suppressing closed-state inactivation, Biophysical Journal, 107: 1090-1104

Yang, F., and J. Zheng (2014) High temperature sensitivity is intrinsic to voltage-gated potassium channels, eLife, e03255

Ma, L., B.H. Lee, R. Mao, A. Cai, Y. Jia, H. Clifton, S. Schaefer, L. Xu, and J. Zheng (2014) Nicotinic acid activates the capsaicin receptor TRPV1 - a potential mechanism for cutaneous flushing, Arteriosclerosis, Thrombosis, and Vascular Biology, 34:1273-1280 ** Editorial Highlight by Dr. Stefan Offermanns (2014) ATVB 34:1122-1123.

Ma, L., F. Yang, and J. Zheng (2014) Application of fluorescence resonance energy transfer in studies of biomolecules, Journal of Molecular Structure, 1077:87-100

Yang, F., L. Ma, X. Cao, K.W. Wang, and J. Zheng (2014) Divalent cations activate TRPV1 through promoting conformational change of the extracellular region, Journal of General Physiology, 143(1): 91-103

Cao, X., F. Yang, L. Ma, K.W. Wang, and J. Zheng (2014) Divalent cations potentiate TRPV1 channel by lowering the heat activation threshold, Journal of General Physiology, 143(1): 75-90

2013

Zheng, J. (2013) Domain-domain interactions in ion channel, Journal of General Physiology, 142(4):347-350.

Lei, L., X. Cao, F. Yang, D.-J. Shi, Y.-Q. Tang, J. Zheng¶ and K.W. Wang¶ (2013) A TRPV4 Channel C-Terminal Segment Plays a Critical Role in Protein Folding and Trafficking, Journal of Biological Chemistry 288: 10427-10439 (¶ corresponding authors)

Zheng, J. and F. Yang (2013) Patch fluorometry (version 2), in: Encyclopedia of Life Sciences (ELS), John Wiley & Sons, Ltd: Chichester

Zheng, J. (2013) Molecular mechanism of TRP channels, Comprehensive Physiology, 3:221-242.

2012

Jin, B., H. Wulff, J. Widdicombe, J. Zheng, D. Bers, and J. Puglisi (2012) A Simple Device to Illustrate the Einthoven Triangle, Advances in Physiology Education, 36:319-324.

Cheng, W., J. Liu, C. Sun, and J. Zheng (2012) Temperature-Sensitive TRP Ion Channels as Drug Targets for Neuropathic Pain, Progress in Physiological Sciences, 43(2): 125-130.

Cao, X., F. Yang, J. Zheng¶, and K.W. Wang¶ (2012) Intracellular proton-mediated activation of TRPV3 channels accounts for exfoliation effect of alpha hydroxyl acids on keratinocytes, Journal of Biological Chemistry, 287(31): 25905-25916 (¶ corresponding authors).

Cui, Y., F. Yang, X. Cao, V. Yarov-Yarovoy, K.W. Wang, J. Zheng (2012) Selective disruption of high-sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations, Journal of General Physiology, 139 (4)273-283.

• Featured on the cover

Cheng, W., F. Yang, S. Liu, C.K. Colton, C. Wang, Y. Cui, X. Cao, M.X. Zhu, C. Sun, K.W. Wang, and J. Zheng (2012) Heteromeric Heat-Sensitive TRP Channels Exhibit Distinct Temperature and Chemical Response, Journal of Biological Chemistry, 287(10): 7279-7288.

2011

Zhang, F., S. Liu, F. Yang, J. Zheng¶, K.W. Wang¶ (2011) Identification of a tetrameric assembly domain in the C-terminus of heat-activated TRPV1 channels, Journal of Biological Chemistry, 286(17):15308-15316 (¶ corresponding authors).

Ma, L., G.Y. Rychkov, E.A. Bykova, J. Zheng, and A.H. Bretag (2011) Lateral displacement of hCLC-1 carboxyl termini during common gating and limits on their cytoplasmic location, Biochemical Journal, 436:415-428.

Yang, F., and J. Zheng (2011) Fluorescence microscopy in thermoTRP channel research, in: TRP Channels, CRC Press, Taylor & Francis Group: Boca Raton.

Dong, B., W. Cheng, W. Li, D. Wu, J. Zheng, F. Matsumura, C.F.A. Vogel (2011) FRET analysis of protein tyrosine kinase c-Src activation mediated via aryl hydrocarbon receptor, Biochimica et Biophysica Acta, 1810:427-451.

2010 - 2004

Cheng, W., C. Sun, and J. Zheng (2010) Heteromerization of TRP channel subunits: Extending functional diversity, Protein & Cell, 1(9):802-810.

Yang, F., Y. Cui, K.W. Wang, and J. Zheng (2010) Thermosensitive TRP channel outer pore is part of the temperature activation pathway, Proceedings of the National Academy of Sciences, 107:7083-7088.

• Highlighted in Cell (2010) 141:377 and Faculty 1000 Biology

Praporski, S., S.M. Ng, A.D. Nguyen, C. Corbin, A. Mechler, J. Zheng, A. Conley, and L. Martin (2009) Organization of enzymes involved in sex steroid synthesis: protein-protein interactions in lipid membranes, Journal of Biological Chemistry, 284:33224-33232.

Qiu, S., X.-M. Zhang, J.-Y. Cao, W. Yang, Y.-G. Yan, L. Shan, J. Zheng, and J.-H. Luo (2009) An ER retention signal located in the extracellular amino-terminal domain of NR2A subunit of NMDA receptors, Journal of Biological Chemistry, 284:20285-20298.

Qu, Z., W. Cheng, Y. Cui, Y. Cui, and J. Zheng (2009) Human disease-causing mutations disrupt an N-C terminal interaction and channel function of bestrophin 1, Journal of Biological Chemistry, 284:16473-16481.

Sun, P., J. Wang, W. Gu, W. Cheng, G.-Z. Jin, E. Friedman, J. Zheng, and X. Zhen (2009) PSD-95 regulates D1 dopamine receptor resensitization, but not receptor-mediated Gs-protein activation, Cell Research 19:612-624.

Liang, S.-S., F. Yang, C. Zhou, Y. Wang, S. Li, C.K. Sun, J.L. Puglisi, D. Bers, C. Sun, and J. Zheng (2009) Temperature-dependent activation of neurons by continuous near-infrared laser, Cell Biochemistry and Biophysics, 53(1), 33-42.

Zheng, J., and K. Matulef (2009) Cyclic nucleotide-gated ion channels, In: Encyclopedia of Life Sciences (ELS), John Wiley & Sons, Ltd: Chichester.

Zheng, J. (2009) FRET and its biological application as a molecular ruler, in Handbook of Modern Biophysics, Vol. 3: Biomedical Applications in Biophysics, Humana Press.

Bykova, E.A. and J. Zheng (2009) Spectra FRET, a fluorescence resonance energy transfer method in live cells, Annual Reviews in Fluorescence 2007, Chapter 4, Springer.

Zheng, J. (2008) Patch fluorometry, In: Encyclopedia of Life Sciences (ELS), John Wiley & Sons, Ltd: Chichester.

Chen, T.Y., Y.F. Lin, and J. Zheng (2008) Electrophysiological measurements of membrane proteins, in Handbook on Biophysics, Vol. 1, Chapter 5, Humana Press.

Vetter, I., W. Cheng, M. Peiris, B.D. Wyse, S.J. Roberts-Thomson, J. Zheng, G.R. Monteith, P.J. Cabot (2008) Rapid, opioid-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization, Journal of Biological Chemistry, 283, 19540-19550.

Ying, G., S.S. Liu, S. Qiu, W. Cheng, J. Zheng, J.H. Luo (2007) Fluorescence resonance energy transfer analysis of subunit assembly of the ASIC channel, Biochemical and Biophysical Research Communications, 359, 143-150.

Cheng, W., F. Yang, C.L. Takanishi, and J. Zheng (2007) Thermosensitive TRPV Channel Subunits Co-assemble into Heteromeric Channels with Intermediate Conductance and Gating Properties, Journal of General Physiology, 129, 191-207.

• Featured on the cover

Zheng, J. (2006) Patch fluorometry: shedding new light on ion channels, Physiology, 21, 6-12.

Cheng, W., and J. Zheng (2006) Applying fluorescence resonance energy transfer (FRET) techniques in live cells studies, Trends in Neurosciences [Chinese], 4, 562-570.

Zheng, J. (2006) Spectroscopy-based quantitative fluorescence resonance energy transfer analysis, Methods in Molecular Biology, 337, 65-78.

Bykova, E.A., X.D. Zhang, T.Y. Chen, and J. Zheng (2006) Large movement in the C terminus of CLC-0 chloride channel during slow gating, Nature Structural and Molecular Biology, 13, 1115-1119.

Takanishi, C.L., E.A. Bykova, W. Cheng, and J. Zheng (2006) Quantification of GFP-based FRET in live cells, Brain Research, 1091(1), 132-139.

Zheng, J. and W.N. Zagotta (2004), Stoichiometry and assembly of olfactory cyclic nucleotide-gated channels, Neuron, 42, 411-421.

Pre - 2004

Zheng, J., M.D. Varnum, and W.N. Zagotta (2003) Disruption of an intersubunit interaction underlies Ca2+-calmodulin modulation of cyclic nucleotide-gated channels, Journal of Neuroscience, 23(22): 8167-8175.

Zheng, J., and W.N. Zagotta (2003) Patch-clamp fluorometry recording of conformational rearrangements of ion channels, Science’s STKE, pl7.

Zheng, J., M.C. Trudeau, and W.N. Zagotta (2002) Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit, Neuron, 36: 891-896.

• Commentary in Nature Review Neuroscience 4(1):10
• Commentary in Neuron 36: 997-999

Zheng, J., L. Venkataramanan, and F.J. Sigworth (2001) Hidden Markov model analysis of intermediate gating steps associated with the pore gate of Shaker potassium channels, Journal of General Physiology, 118: 547-562.

Zheng, J., and W.N. Zagotta (2000) Gating rearrangements in cyclic nucleotide-gated channels revealed by patch-clamp fluorometry, Neuron, 28: 369-374.

Zheng, J., and F.J. Sigworth (1998) Intermediate conductances during deactivation of heteromultimeric Shaker potassium channels, Journal of General Physiology, 112: 457-474.

Zheng, J., and F.J. Sigworth (1997) Selectivity changes during activation of mutant Shaker potassium channels, Journal of General Physiology, 110: 101-117.

• Featured on the cover

Mathur, R., J. Zheng, Y. Yan, and F.J. Sigworth (1997) Role of the S3-S4 linker in Shaker potassium channel activation, Journal of General Physiology, 109: 191-200.

Zhang, R.J., D.J. Zou, and J. Zheng (1995) Correlation of receptive field position of mechanosensory neurons and the strength of their connections to AP neurons in the CNS of the leech (Whitmania pigra), Invertebrate Neuroscience, 1: 249-254.

Zhang, R.J., D.J. Zou, J. Zheng, and W.H. Xiong (1992) Positional discrimination of the AP neuron synapses in the leech Whitmania pigra, Science in China, Series B, 12: 1287-1294.

Liu, K.Q., J. Zheng, Y.Q. Lu, Y.H. Zhang, and F. Liu (1991) Automatic analysis of single-channel records, Acta Biophysica Sinica, 7(3): 346-351.