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Our Publications

publications


∗In chronological order

Bibliography

  1. Nguyen PT, Nguyen HM, Wagner KM, Stewart RG, Singh V, Thapa P, Chen Y-J, Lillya MW, Ton AT, Kondo R, Ghetti A, Pennington MW, Hammock BD, Griffith TN, Sack JT, Wulff H, Yarov-Yarovoy V (2022) Computational design of peptides to target Nav1.7 channel with high potency and selectivity for the treatment of pain. bioRxiv. doi: 10.1101/2022.07.21.500925
  2. Maly J, Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V (2022) Structural modeling of the hERG potassium channel and associated drug interactions. Front Pharmacol. 13:966463. doi: 10.3389/fphar.2022.966463.
  3. Nguyen PT and Yarov-Yarovoy V (2022) Towards Structure-Guided Development of Pain Therapeutics Targeting Voltage-Gated Sodium Channels. Front Pharmacol 13: 842032. doi: 10.3389/fphar.2022.842032.
  4. Ledford HA, Ren L, Thai PN, Park S, Timofeyev V, Sirish P, Xu W, Emigh AM, Priest JR, Perez MV, Ashley EA, Yarov-Yarovoy V, Yamoah EN, Zhang XD, Chiamvimonvat N (2022) Disruption of protein quality control of the human ether-à-go-go related gene K + channel results in profound long QT syndrome. Heart Rhythm. S1547-5271(21)02221-9. doi: 10.1016/j.hrthm.2021.10.005.
  5. Pumroy RA, Protopopova AD, Fricke TC, Lange IU, Haug FM, Nguyen PT, Gallo PN, Sousa BB, Bernardes GJL, Yarov-Yarovoy V, Leffler A, Moiseenkova-Bell VY (2022) Structural insights into TRPV2 activation by small molecules. Nat Commun. 13(1):2334. doi: 10.1038/s41467-022-30083-3.
  6. George K, Lopez-Mateos D, Abd El-Aziz TM, Xiao Y, Kline J, Bao H, Raza S, Stockand JD, Cummins TR, Fornelli L, Rowe MP, Yarov-Yarovoy V, Rowe AH (2022) Structural and Functional Characterization of a Novel Scorpion Toxin that Inhibits NaV1.8 via Interactions With the DI Voltage Sensor and DII Pore Module. Front Pharmacol. 13:846992. doi: 10.3389/fphar.2022.846992.
  7. Mazola Y, Márquez Montesinos JCE, Ramírez D, Zúñiga L, Decher N, Ravens U, Yarov-Yarovoy V, González W (2022) Common Structural Pattern for Flecainide Binding in Atrial-Selective Kv1.5 and Nav1.5 Channels: A Computational Approach. Pharmaceutics 14(7):1356. doi: 10.3390/pharmaceutics14071356.
  8. Koehler Leman J, Lyskov S, Lewis SM, Adolf-Bryfogle J, Alford RF, Barlow K, Ben-Aharon Z, Farrell D, Fell J, Hansen WA, Harmalkar A, Jeliazkov J, Kuenze G, Krys JD, Ljubetič A, Loshbaugh AL, Maguire J, Moretti R, Mulligan VK, Nance ML, Nguyen PT, Ó Conchúir S, Roy Burman SS, Samanta R, Smith ST, Teets F, Tiemann JKS, Watkins A, Woods H, Yachnin BJ, Bahl CD, Bailey-Kellogg C, Baker D, Das R, DiMaio F, Khare SD, Kortemme T, Labonte JW, Lindorff-Larsen K, Meiler J, Schief W, Schueler-Furman O, Siegel JB, Stein A, Yarov-Yarovoy V, Kuhlman B, Leaver-Fay A, Gront D, Gray JJ, Bonneau R (2021) Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks. Nat Commun 12(1):6947. doi: 10.1038/s41467-021-27222-7.
  9. Xu L, Zhang H, Wang Y, Lu X, Zhao Z, Ma C, Yang S, Yarov-Yarovoy V, Tian Y, Zheng J, Yang F (2021) De Novo Design of Peptidic Positive Allosteric Modulators Targeting TRPV1 with Analgesic Effects. Adv Sci (Weinh):e2101716. doi: 10.1002/advs.202101716.
  10. DeMarco KR, Yang PC, Singh V, Furutani K, Dawson JRD, Jeng MT, Fettinger JC, Bekker S, Ngo VA, Noskov SY, Yarov-Yarovoy V, Sack JT, Wulff H, Clancy CE, Vorobyov I (2021) Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline. J Mol Cell Cardiol. 158: 163-177. doi: 10.1016/j.yjmcc.2021.05.015.
  11. Kisiela DI, Magala P, Interlandi G, Carlucci LA, Ramos A, Tchesnokova V, Basanta B, Yarov-Yarovoy V, Avagyan H, Hovhannisyan A, Thomas WE, Stenkamp RE, Klevit RE, Sokurenko EV (2021) Toggle switch residues control allosteric transitions in bacterial adhesins by participating in a concerted repacking of the protein core. PLoS Pathog. 17(4): e1009440. doi: 10.1371/journal.ppat.1009440.
  12. Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L. (2020) Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell 183(7): 1986-2002.e26. doi: 10.1016/j.cell.2020.11.040.
  13. Ledford HA, Park S, Muir D, Woltz RL, Ren L, Nguyen PT, Sirish P, Wang W, Sihn CR, George AL, Knollmann BC, Yamoah EN, Yarov-Yarovoy V, Zhang XD, Chiamvimonvat N. (2020) Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation. J Gen Physiol. 152(12): e202012667. doi: 10.1085/jgp.202012667.
  14. Vu S, Singh V, Wulff H, Yarov-Yarovoy V, Zheng J. (2020) New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket. Elife 9: e62039. doi: 10.7554/eLife.62039.
  15. Yang F, Xu L, Lee BH, Xiao X, Yarov-Yarovoy V, Zheng J. (2020) An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel. Adv Sci 7(20): 2000575. doi: 10.1002/advs.202000575.
  16. Koehler Leman J, Weitzner BD, Renfrew PD, Lewis SM, Moretti R, Watkins AM, Mulligan VK, Lyskov S, Adolf-Bryfogle J, Labonte JW, Krys J; Yarov-Yarovoy V (RosettaCommons Consortium), Bystroff C, Schief W, Gront D, Schueler-Furman O, Baker D, Bradley P, Dunbrack R, Kortemme T, Leaver-Fay A, Strauss CEM, Meiler J, Kuhlman B, Gray JJ, Bonneau R. (2020) Better together: Elements of successful scientific software development in a distributed collaborative community. PLoS Comput Biol. 16(5): e1007507. doi: 10.1371/journal.pcbi.1007507.
  17. Li G, Woltz RL, Wang CY, Ren L, He PX, Yu SD, Liu XQ, Yarov-Yarovoy V, Hu D, Chiamvimonvat N, Wu L. (2020) Gating Properties of Mutant Sodium Channels and Responses to Sodium Current Inhibitors Predict Mexiletine-Sensitive Mutations of Long QT Syndrome 3. Front Pharmacol 11: 1182. doi: 10.3389/fphar.2020.01182.
  18. Fletcher-Taylor S, Thapa P, Sepela RJ, Kaakati R, Yarov-Yarovoy V, Sack JT, Cohen BE (2020) Distinguishing Potassium Channel Resting State Conformations in Live Cells with Environment-Sensitive Fluorescence. ACS Chem Neurosci. Online ahead of print. doi: 10.1021/acschemneuro.0c00276.
  19. Perez-Flores MC, Lee JH, Park S, Zhang XD, Sihn CR, Ledford HA, Wang W, Kim HJ, Timofeyev V, Yarov-Yarovoy V, Chiamvimonvat N, Rabbitt RD, Yamoah EN (2020) Cooperativity of Kv7.4 channels confers ultrafast electromechanical sensitivity and emergent properties in cochlear outer hair cells. Sci Adv. 6(15): eaba1104. doi: 10.1126/sciadv.aba1104.
  20. Rudell JC, Borges LS, Yarov-Yarovoy V, Ferns M (2020) The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking. Front Mol Neurosci. 13: 48. doi: 10.3389/fnmol.2020.00048.
  21. Yang PC, DeMarco KR, Aghasafari P, Jeng MT, Dawson JRD, Bekker S, Noskov SY, Yarov-Yarovoy V, Vorobyov I, Clancy CE (2020) A Computational Pipeline to Predict Cardiotoxicity: From the Atom to the Rhythm. Circ Res. 126(8): 947-964. doi: 10.1161/CIRCRESAHA.119.316404.
  22. Turner M, Anderson DE, Bartels P, Nieves-Cintron M, Coleman AM, Henderson PB, Man KNM, Tseng PY, Yarov-Yarovoy V, Bers DM, Navedo MF, Horne MC, Ames JB, Hell JW (2020) α-Actinin-1 promotes activity of the L-type Ca2+ channel Cav 1.2. EMBO J. 39(5): e102622. doi: 10.15252/embj.2019102622.
  23. Craig RA 2nd, Garrison CE, Nguyen PT, Yarov-Yarovoy V**, Du Bois J** (2020) Veratridine: A Janus-Faced Modulator of Voltage-Gated Sodium Ion Channels. ACS Chem Neurosci. 11(3): 418-426. doi: 10.1021/acschemneuro.9b00621.
  24. Shim H, Brown BM, Singh L, Singh V, Fettinger JC, Yarov-Yarovoy V, Wulff H (2019) The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators. Front Pharmacol. 10:972. doi: 10.3389/fphar.2019.00972.
  25. Yarov-Yarovoy V, DeCaen PG (2019) The Sodium Channel Voltage Sensor Slides to Rest. Trends Pharmacol Sci. pii: S0165-6147(19) 30195-6. doi: 10.1016/j.tips.2019.08.009.
  26. Ng LCT, Vien TN, Yarov-Yarovoy V, DeCaen PG (2019) Opening TRPP2 (PKD2L1) requires the transfer of gating charges. Proc Natl Acad Sci USA 116(31): 15540-15549. doi: 10.1073/pnas.1902917116.
  27. Dong Y, Yin Y, Vu S, Yang F, Yarov-Yarovoy V, Tian Y, Zheng J (2019) A distinct structural mechanism underlies TRPV1 activation by piperine. Biochem Biophys Res Commun. 516(2): 365-372. doi: 10.1016/j.bbrc.2019.06.039.
  28. Yin Y, Dong Y, Vu S, Yang F, Yarov-Yarovoy V, Tian Y, Zheng J (2019) Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers. Br J Pharmacol. 176: 3364-3377. doi: 10.1111/bph.14766.
  29. Kimball IH, Nguyen PT, Olivera BM, Sack JT, Yarov-Yarovoy V (2019) Molecular Determinants of μ-Conotoxin KIIIA interaction with the Voltage-Gated Sodium Channel Nav1.7. bioRxiv. doi: https://doi.org/10.1101/654889.
  30. Rudell JB, Maselli RA, Yarov-Yarovoy V, Ferns MJ (2019) Pathogenic effects of agrin V1727F mutation are isoform-specific and decrease its expression and affinity for HSPGs and LRP4. Hum Mol Genet. 28(16): 2648-2658. doi: 10.1093/hmg/ddz081.
  31. Heeney DD, Yarov-Yarovoy V, Marco ML (2019) Sensitivity to the two peptide bacteriocin plantaricin EF is dependent on CorC, a membrane-bound, magnesium/cobalt efflux protein. Microbiologyopen. 2019 Mar 19:e827. doi: 10.1002/mbo3.827. [Epub ahead of print].
  32. Noskov SY, Yarov-Yarovoy V (2019) Editorial. Neurosci Lett. 700: 1-2. doi: 10.1016/j.neulet.2019.02.040.
  33. Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V (2019) Antibodies and venom peptides: new therapeutic modalities for ion channels. Nature Reviews Drug Discovery 18(5): 339-357. doi: 10.1038/s41573-019-0013-8.
  34. Nguyen PT, DeMarco KR, Vorobyov I, Clancy CE, Yarov-Yarovoy V (2019) Structural Basis of Antiarrhythmic Drug Interactions with the Human Cardiac Sodium Channel. Proc Natl Acad Sci USA 116(8): 2945-2954. doi: 10.1073/pnas.1817446116.
  35. Yang F, Xiao X, Lee BH, Vu S, Yang W, Yarov-Yarovoy V, Zheng J (2018) The conformational wave in capsaicin activation of Transient Receptor Potential Vanilloid 1 ion channel. Nat Commun. 9: 2879. doi: 10.1038/s41467-018-05339-6.
  36. Brown BM, Shim H, Zhang M, Yarov-Yarovoy V, Wulff H (2017) Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121). Molecular Pharmacology [Epub ahead of print] doi: 10.1124/mol.117.109421.
  37. Tanaka BS, Nguyen PT, Zhou EY, Yang Y, Yarov-Yarovoy V, Dib-Hajj SD, Waxman SG (2017) Gain-of-function mutation of a voltage-gated sodium channel Nav1.7 associated with peripheral pain and impaired limb development. J Biol Chem. 292, 9262-9272. doi: 10.1074/jbc.M117.778779.
  38. Tang C, Zhou X, Nguyen PT, Zhang Y, Hu Z, Zhang C, Yarov-Yarovoy V, DeCaen PG, Liang S, Liu Z (2017) A novel tarantula toxin stabilizes the deactivated voltage sensor of bacterial sodium channel. FASEB J. 31, 3167-3178. doi: 10.1096/fj.201600882R.
  39. Zhang P, Zawadzki RJ, Goswami M, Nguyen PT, Yarov-Yarovoy V, Burns ME, Pugh EN Jr. (2017) In vivo optophysiology reveals that G-protein activation triggers osmotic swelling and increased light scattering of rod photoreceptors. Proc Natl Acad Sci USA 114, E2937-E2946. doi: 10.1073/pnas.1620572114.
  40. Nguyen HM, Singh V, Pressly B, Jenkins DP, Wulff H, Yarov-Yarovoy V (2017) Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore. Molecular Pharmacology 91, 392-402. doi: 10.1124/mol.116.108068.
  41. Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V (2017) Potassium channels in the heart: structure, function and regulation. Journal of Physiology 595, 2209-2228. doi: 10.1113/JP272864.
  42. Kaur I, Yarov-Yarovoy V, Kirk LM, Plambeck KE, Barragan EV, Ontiveros ES, Díaz E (2016) Activity-Dependent Palmitoylation Controls SynDIG1 Stability, Localization, and Function. J Neurosci. 36, 7562-8. doi: 10.1523/JNEUROSCI.4859-14.2016.
  43. Becker EA, Yao AI, Seitzer PM, Kind T, Wang T, Eigenheer R, Shao KS, Yarov-Yarovoy V, Facciotti MT (2016) A Large and Phylogenetically Diverse Class of Type 1 Opsins Lacking a Canonical Retinal Binding Site. PLoS One 11, e0156543. doi: 10.1371/journal.pone.0156543.
  44. Yang F, Vu S, Yarov-Yarovoy V, Zheng J (2016) Rational design and validation of a vanilloid-sensitive TRPV2 ion channel. Proc Natl Acad Sci U S A 113, E3657-66. doi: 10.1073/pnas.1604180113.
  45. Tuluc P*, Yarov-Yarovoy V*, Benedetti B, Flucher BE (2016) Molecular Interactions in the Voltage Sensor Controlling Gating Properties of Cav Calcium Channels. Structure 24, 261-71. doi: 10.1016/j.str.2015.11.011.
  46. Sihn CR, Kim HJ, Woltz RL, Yarov-Yarovoy V, Yang PC, Xu J, Clancy CE, Zhang XD, Chiamvimonvat N, Yamoah EN (2016) Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels. J. Biol. Chem. 291, 2499-509. doi: 10.1074/jbc.M115.668236.
  47. Yang S, Yang F, Xiao X, Wei N, Hong J, Li B, Luo L, Rong M, Yarov-Yarovoy V, Zheng J, Wang K, Lai R (2015) A Pain-Inducing Centipede Toxin Targets the Heat Activation Machinery of Nociceptor TRPV1. Nat Commun. 6, 8297. doi: 10.1038/ncomms9297.
  48. Schmidt EM, Wiek C, Parkinson OT, Roellecke K, Freund M, Gombert M, Lottmann N, Steward CA, Kramm CM, Yarov-Yarovoy V, Rettie AE, and Hanenberg H (2015) Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution. PLoS One 10, e0137110. doi: 10.1371/journal.pone.0137110.
  49. Kaur G, Pinggera A, Ortner NJ, Lieb A, Sinnegger-Brauns MJ, Yarov-Yarovoy V, Obermair GJ, Flucher BE, Striessnig J (2015) A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-Gated Cav1.2 Calcium Channel Function. J. Biol. Chem. 290, 21086-100. doi: 10.1074/jbc.M115.645671.
  50. Yang F, Xiao X, Cheng W, Yang W, Yu P, Song Z, Yarov-Yarovoy V, Zheng J (2015) Structural mechanism underlying capsaicin binding and activation of nociceptive TRPV1 ion channel. Nat Chem Biol. 11, 518-24. doi: 10.1038/nchembio.1835.
  51. Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Yarov-Yarovoy V, Kim JI, Swartz KJ (2015) Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels. eLife 4, e06774. doi: 10.7554/eLife.06774.
  52. Wiek C, Schmidt EM, Roellecke K, Freund M, Nakano M, Kelly EJ, Kaisers W, Yarov-Yarovoy V, Kramm CM, Rettie AE, Hanenberg H (2015) Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol. Biochem J. 465, 103-14. doi: 10.1042/BJ20140813.
  53. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM (2015) Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 593, 1347-60. doi: 10.1113/jphysiol.2014.281428.
  54. Tilley DC, Eum KS, Fletcher-Taylor S, Austin DC, Dupré C, Patrón L, Garcia R, Lam K, Yarov-Yarovoy V, Cohen BE, and Sack JT (2014) Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells. Proc Natl Acad Sci U S A 111, E4789-96. doi: 10.1073/pnas.1406876111.
  55. Yarov-Yarovoy V, Allen TW, and Clancy CE (2014) Computational Models for Predictive Ion Channel Pharmacology. Drug Discovery Today: Disease Models 14, 3-10. PMID: 26635886.
  56. Boiteux C, Vorobyov I, French RJ, French C, Yarov-Yarovoy V, Allen TW (2014) Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A 111, 13057-62. doi: 10.1073/pnas.1408710111.
  57. Rafizadeh S, Zhang Z, Woltz RL, Kim HJ, Myers RE, Lu L, Tuteja D, Singapuri A, Bigdeli AAZ, Harchache SB, Knowlton AA, Yarov-Yarovoy V, Yamoah EN, and Chiamvimonvat N (2014) Functional interaction with filamin A enhances the surface membrane expression of a small-conductance Ca2+ -activated K+ (SK2) channel. Proc Natl Acad Sci U S A 111, 9989-9994. doi: 10.1073/pnas.1323541111.
  58. Wulff H and Yarov-Yarovoy V (2013) Channels: Sticking to nooks and crannies. Nat Chem Biol. 9, 473-4.
  59. Timofeyev V, Myers RE, Kim HJ, Woltz RL, Sirish P, Heiserman JP, Li N, Singapuri A, Tang T, Yarov-Yarovoy V, Yamoah EN, Hammond HK, and Chiamvimonvat N (2013) Adenylyl Cyclase Subtype–Specific Compartmentalization Differential Regulation of L-Type Ca2+ Current in Ventricular Myocytes. Circulation Res. 112, 1567-76.
  60. Acar S, Carlson D, Budamagunta M, Yarov-Yarovoy V, Correia JJ, Niñonuevo MR, Jia W, Tao L, Leary JA, Voss J, Evans JE, and Scholey JM (2013) The Bipolar Assembly Domain of the Mitotic Motor Kinesin-5. Nat Commun 4, 1343.
  61. Khafagaa M, Bossuyt J, Mamikoniana L, Lia JC, Lee LL, Yarov-Yarovoy V, Despa S, and Bers DM (2012) Na+/K+-ATPase E960 and Phospholemman F28 are critical for their functional interaction. Proc Natl Acad Sci U S A 109, 20756-61.
  62. Vargas E, Yarov-Yarovoy V, Khalili-Aragi F, Catterall WA, Klein ML, Tarek M, Lindahl E, Schulten K, Perozo E, Bezanilla F, and Roux B (2012) An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations. J Gen Physiol 140, 587-94.
  63. Zhang JZ, Yarov-Yarovoy V, Scheuer T, Karbat I, Cohen L, Gordon D, Gurevitz M, and Catterall WA (2012) Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated sodium channels. J. Biol. Chem. 287, 30719-28.
  64. Cui Y, Yang F, Cao X, Yarov-Yarovoy V, Wang K, Zheng J (2012) Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. J Gen Physiol. 139, 273-83.
  65. Watschinger K, Fuchs JE, Yarov-Yarovoy V, Keller MA, Golderer G, Hermetter A, Werner-Felmayer G, Hulo N, Werner ER (2012) Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase. Biochem J. 443, 279-86.
  66. Yarov-Yarovoy V*, DeCaen PG*, Westenbroek, RE, Pan C-Y, Scheuer T, Baker D, and Catterall WA (2012) Structural Basis for Gating Charge Movement in the Voltage Sensor of a Sodium Channel. Proc Natl Acad Sci U S A 109, E93-E102.
  67. Maselli RA, Fernandez JM, Arredondo J, Navarro C, Ngo M, Beeson D, Cagney O, Williams DC, Wollmann RL, Yarov-Yarovoy V, and Ferns MJ (2012) LG2 agrin mutation causing severe congenital myasthenic syndrome mimics functional characteristics of non-neural (z-) agrin. Hum Genet. 131, 1123-35.
  68. Oganesian A, Yarov-Yarovoy V, Parks WC, and Schwinn DA (2011) Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway. Proc Natl Acad Sci U S A 108, 19796-19801.
  69. DeCaen PG, Yarov-Yarovoy V, Scheuer T, and Catterall WA (2011) Gating Charge Interactions with the S1 Segment During Activation of a Na+ Channel Voltage Sensor. Proc Natl Acad Sci U S A 108, 18825-18830.
  70. Wang J, Yarov-Yarovoy V, Kahn R, Gordon D, Gurevitz M, Scheuer T, and Catterall WA (2011) Mapping the receptor site for α-scorpion toxins on Na+ channel voltage sensor. Proc Natl Acad Sci U S A 108, 15426-15431.
  71. Zhang JZ, Yarov-Yarovoy V, Scheuer T, Karbat I, Cohen L, Gordon D, Gurevitz M, and Catterall WA (2011) Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels. J. Biol. Chem. 286, 33641-33651.
  72. Kisiela DI, Kramer JJ, Tchesnokova V, Aprikian P, Yarov-Yarovoy V, Clegg S, and Sokurenko EV (2011) Allosteric catch bond properties of the FimH adhesin from Salmonella enterica serovar Typhimurium. J. Biol. Chem. 286, 38136-38147.
  73. Kelly EJ, Nakano M, Rohatgi P, Yarov-Yarovoy V, and Rettie AE (2011) Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states. Mol Interv. 11, 124-132.
  74. Subbotina J*, Yarov-Yarovoy V*, Lees-Miller J, Durdagi S, Guo J, Duff HJ, and Noskov SY (2010) Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations. Proteins 78, 2922-2934.
  75. Khalili-Araghi F, Jogini V, Yarov-Yarovoy V, Tajkhorshid E, Roux B, and Schulten K (2010) Calculation of the Gating Charge for the Kv1.2 Voltage-Activated Potassium Channel. Biophys. J. 98, 2189-2198.
  76. Catterall WA and Yarov-Yarovoy V (2010) Helical motion of an S4 voltage sensor revealed by gating pore currents. Channels 4, 75-77.
  77. DeCaen PG, Yarov-Yarovoy V, Sharp EM, Scheuer T, and Catterall WA (2009) Sequential formation of ion pairs during voltage-dependent activation of a sodium channel. Proc Natl Acad Sci U S A 106, 22498-22503.
  78. Lees-Miller JP, Subbotina JO, Guo J, Yarov-Yarovoy V, Noskov SY, Duff HJ (2009) Interactions of H562 in the S5 helix with T618 and S621 in the pore helix are important determinants of hERG1 potassium channel structure and function. Biophys J. 96, 3600-3610.
  79. DeCaen PG, Yarov-Yarovoy V, Zhao Y, Scheuer T, and Catterall WA (2008) Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation. Proc Natl Acad Sci U S A 105, 15142-15147.
  80. Pathak* MM, Yarov-Yarovoy V*, Agarwal G, Roux B, Barth P, Kohout S, Tombola F and Isacoff EY (2007) Plunging the Shaker K+ channel to rest. Neuron 56, 124-140.
  81. Catterall WA, Cestele S, Yarov-Yarovoy V, Yu FH, Konoki K, and Scheuer T (2007) Voltage-gated ion channels and gating modifier toxins. Toxicon 49, 124-141.
  82. Aprikian P, Tchesnokova V, Kidd B, Yakovenko O, Yarov-Yarovoy V, Trinchina E, Vogel V, Thomas W, Sokurenko E (2007) Interdomain interaction in the FimH adhesin of Escherichia coli regulates the affinity to mannose. J. Biol. Chem. 282, 23437-23446.
  83. Yarov-Yarovoy V, Baker D, and Catterall WA (2006) Voltage Sensor Conformations in the Open and Closed States in Rosetta Structural Models of K+ Channels. Proc Natl Acad Sci U S A 103, 7292-7297.
  84. Yarov-Yarovoy V*, Schonbrun J*, and Baker D (2006) Multipass Membrane Protein Structure Prediction Using Rosetta. Proteins 62, 1010-1025.
  85. Hulme JT, Yarov-Yarovoy V, Lin TWC, Scheuer T, and Catterall WA (2006) Autoinhibitory Control of the Cav1.2 Channel by its Proteolytically Processed Distal C-terminal Domain. J. Physiol. 103(44), 16574-16579.
  86. Cestèle S, Yarov-Yarovoy V, Qu Y, Sampieri F, Scheuer T, and Catterall WA (2006) Structure and Function of the Voltage Sensor of Sodium Channels Probed by a β-Scorpion Toxin. J. Biol. Chem. 281, 21332-21344.
  87. Yu F, Yarov-Yarovoy V, Gutman GA, and Catterall WA (2005) Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacol Rev. 57, 387-395.
  88. Zhao Y, Yarov-Yarovoy V, Scheuer T, and Catterall WA (2004) The Gating Hinge of a Voltage-Gated Sodium Channel: A Molecular Switch Controlling Electrical Signaling. Neuron, 41(6), 859-865.
  89. Liu G, Yarov-Yarovoy V, Nobbs M, Clare JJ, Scheuer T, and Catterall WA (2003) Differential Interactions of Lamotrigine and Related Drugs with Transmembrane Segment IVS6 of Voltage-Gated Sodium Channels. Neuropharmacology, 44, 413-422.
  90. Yarov-Yarovoy V, McPhee JC, Idsvoog D, Pate C, Scheuer T, and Catterall WA (2002) Role of Amino Acid Residues in Transmembrane Segments IS6 and IIS6 of the Na+ Channel a Subunit in Voltage-dependent Gating and Drug Block. J. Biol. Chem., 277, 35393-35401.
  91. Yarov-Yarovoy Y, Brown J, Sharp E, Clare JJ, Scheuer T, and Catterall WA (2001) Molecular Determinants of Voltage-dependent Gating and Binding of Pore-blocking Drugs in Transmembrane Segment IIIS6 of the Na+ a Subunit. J. Biol. Chem., 276, 20-27.
  92. Jaburek M, Yarov-Yarovoy V, Paucek P, and Garlid KD (1998) State-dependent Inhibition of the Mitochondrial KATP Channel by Glyburide and 5-Hydroxydecanoate. J. Biol. Chem., 273, 13578-13582.
  93. Garlid KD, Paucek P, Yarov-Yarovoy V, Murray HN, Darbenzio RB, D'Alonzo AJ, Lodge NJ, Smith MA, and Grover GJ (1997) Cardioprotective Effect of Diazoxide and its Interaction with Mitochondrial ATP-Sensitive Potassium Channels: Possible Mechanism of Cardioprotection. Circulation Res., 81, 1072-1082.
  94. Yarov-Yarovoy V, Paucek P, Jaburek M, and Garlid KD (1997) The Nucleotide Regulatory Sites on the Mitochondrial KATP Channel Face the Cytosol. Biochim. Biophys. Acta., 1321, 128-136.
  95. Mironova GD, Skarga YY, Grigoriev SM, Yarov-Yarovoy V, Alexandrov AV, and Kolomytkin OV (1996) The ATP-Dependent Potassium Channel from Rat Liver Mitochondria. 1. Isolation, Purification, and Reconstitution in a Bilayer Lipid Membrane. Membr. Cell Biol., 10, 429- 437.
  96. Paucek P, Yarov-Yarovoy V, Sun X, and Garlid KD (1996) Inhibition of the Mitochondrial KATP Channel by Long Chain Acyl‑CoA Esters and Activation by Guanine Nucleotides. J. Biol. Chem., 271, 32084-32088.
  97. Garlid KD, Paucek P, Yarov-Yarovoy V, Sun X, and Schindler P (1996) The Mitochondrial KATP Channel as a Receptor for Potassium Channel Openers. J. Biol. Chem., 271, 8796-8799.

* - these authors contributed equally to this paper.

Book Chapters and Reference Works

  1. Yarov-Yarovoy, V (2015) Rosetta Structural Modeling. Handbook of Ion Channels. Zheng J, Trudeau M, editors (CRC Press, Boca Raton, Florida).
  2. Yarov-Yarovoy, V (2012) Toxin-Channel Interactions in K Channels. Encyclopedia of Metalloproteins. Springer Science.
  3. Yu, F, Yarov-Yarovoy, V, Gutman, GA, and Catterall, WA (2005) Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacological Reviews, 57: 387-395.

Abstracts

  1. DeMarco KR, Yang P-C, Aghasafari P, Dawson JRD, Bekker B, Noskov SY, Yarov-Yarovoy V, Vorobyov IV, Clancy CE (2020) Demonstration of a Predictive Multiscale Model for Drug-Induced Arrhythmogenic Risk. Biophys. J. 118 (Issue 3), p325a.
  2. Emigh AM, DeMarco KR, Furutani K, Clancy CE, Vorobyov I, Yarov-Yarovoy V (2020) Predicting Arrhythmogenicity: Structural Modeling of Safe and Unsafe hERG Blockers. Biophys. J. 118 (Issue 3), p117a.
  3. Maly J, Emigh AM, DeMarco KR, Sack JT, Vorobyov I, Clancy CE, Yarov-Yarovoy V (2020) Structural Modeling of the hERG Channel in an Inactivated State and Associated Drug Interactions. Biophys. J. 118 (Issue 3), p212a.
  4. Harris BJ, Nguyen PT, Yarov-Yarovoy V (2020) Structural Modeling of Ion Channel - Small Molecule Interactions using Rosetta's Galiganddock. Biophys. J. 118 (Issue 3), p587a.
  5. Maly J, Emigh AM, DeMarco KR, Sack JT, Vorobyov I, Clancy CE, Yarov-Yarovoy V (2019) Structural Modeling of the hERG Channel In An Inactivated State And Its Drug Interactions. Biophys. J. 116 (Issue 3), p104a.
  6. Yang F, Xiao X, Lee BH, Vu S, Yang W, Yarov-Yarovoy V, Zheng J (2019) The Conformational Wave in Capsaicin Activation of Transient Receptor Potential Vanilloid 1 Ion Channel. Biophys. J. 116 (Issue 3), p452a.
  7. Emigh AM, DeMarco KR, Furutani K, Bekker S, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V (2019) Structural Modeling of Drug Interactions of hERG Channel in Closed and Open States. Biophys. J. 116 (Issue 3), p249a–250a.
  8. DeMarco KR, Dawson JRD, Bekker B, Vorobyov IV, Yarov-Yarovoy V, Noskov SY, Clancy CE (2019) The Molecular Mechanisms of State Dependent Herg Blockade by Dofetilide. Biophys. J. 116 (Issue 3), p245a.
  9. Maly J, Thillier Y, Or G, Lam K, Sack JT, Tian L, Yarov-Yarovoy V (2018) Rational Engineering and Rosetta Design of a Genetically Encoded Fluorescent Reporter of Protein Conformational Change. Biophys. J. 114 (Issue 3), p408a.
  10. Emigh AM, DeMarco KR, Furutani K, Bekker S, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V (2018) Structural Modeling of hERG Channel Interactions with Drugs using Rosetta. Biophys. J. 114 (Issue 3), p486a.
  11. Nguyen PT, DeMarco KR, Vorobyov I, Clancy CE, Yarov-Yarovoy V (2018) Structural Modeling of Local Anesthetic and Antiarrhythmic Drug Binding to the Human Cardiac Voltage Gated Sodium Channel. Biophys. J. 114 (Issue 3), p39a.
  12. Kimball IH, Nguyen PT, Sack JT, Yarov-Yarovoy V (2018) Mapping the Nav1.7 Channel Interaction with the Conotoxin KIIIA. Biophys. J. 114 (Issue 3), p635a.
  13. Kimball IH, Nguyen PT, Yam J, Pressly, B, York, R, Sack JT, Yarov-Yarovoy V (2017) Tarantula Toxin SGTx-1 alters Gating Kinetics of Human Voltage-Gated Sodium Channel Nav1.7. Biophys. J. 112 (Issue 3), 240a.
  14. Yang F, Vu S, Yarov-Yarovoy V, Zheng J (2017) Rational Design and Validation of a Vanilloid-Sensitive TRPV2 Ion Channel. Biophys. J. 112 (Issue 3), 114a.
  15. DeMarco KR, Nguyen PT, Allen TW, Yarov-Yarovoy V, Clancy CE, Vorobyov I (2017) State-Dependent Structural Modeling and Atomistic Simulations of the hERG Potassium Channel. Biophys. J. 112 (Issue 3), 542a.
  16. Shim H, Brown B, Nguyen HM, Yarov-Yarovoy V, Wulff H (2017) Rational Design of KCa2 Channel Activators. Biophys. J. 112 (Issue 3), 412a-413a.
  17. Nguyen PT, DeMarco KR, Vorobyov I, Clancy CE, Allen TW, Yarov-Yarovoy V (2017) An Open State Model of the Navab Channel Explored by Rosetta and Molecular Dynamics Simulation. Biophys. J. 112 (Issue 3), 105a.
  18. Nguyen HM, Latika S, Wulff H, Yarov-Yarovoy V (2016) Validation of KCa3.1 Channel Small Molecules Interaction Sites Predicted by Rosetta. Biophys. J. 110 (Issue 3), p447a.
  19. Yang S, Yang F, Wei N, Hong J, Li B, Luo L, Rong M, Yarov-Yarovoy V, Zheng J, Wang K, Lai R (2016) A Pain-Inducing Centipede Toxin Targets the Heat Activation Machinery of Nociceptor TRPV1. Biophys. J. 110 (Issue 3), p284a.
  20. Brown B, Shim H, Yarov-Yarovoy V, Wulff H (2016) Structural Determinants for Selectivity of the Positive KCa Channel Gating Modulator, SKA-121. Biophys. J. 110 (Issue 3), p114a.
  21. DeMarco KR, Yarov-Yarovoy V, Boiteaux C, Allen TW, Clancy CE (2016) Molecular Scale Prediction of Lidocaine Interaction with the Pore Domain of Human Nav1.5. Biophys. J. 110 (Issue 3), p107a.
  22. Nguyen D, Yarov-Yarovoy V (2016) Design Principles of Membrane Protein Structures. Biophys. J. 110 (Issue 3), p56a.
  23. Tilley DW, Fleishman S, Sack JT, Yarov-Yarovoy V (2016) What Determines the Charybdotoxin Specificity Among Kv1 Potassium Channels? Biophys. J. 110 (Issue 3), p106a–107a.
  24. Kimball IH, Nguyen PT, Sack JT, Yarov-Yarovoy V (2016) Mapping the Nav1.7 Channel Interaction with the Conotoxin KIIIA. Biophys. J. 110 (Issue 3), p437a.
  25. Nguyen PT, Sack JT, Allen TW, Yarov-Yarovoy V (2016) Exploring Structural Interactions of Tarantula Toxins With Lipid Membrane Using Rosetta And Molecular Dynamics Simulation. Biophys. J. 110 (Issue 3), p447a.
  26. Boiteux C, Vorobyov I, French RJ, French C, Yarov-Yarovoy V, Allen TW (2015) Sodium Selective Conduction, Inactivation and Inhibition Mechanisms using the Bacterial NavAb Channel. Biophys. J. 108 (Issue 2), 574a.
  27. Nguyen PT, Kimball IH, Eum KS, Cohen BE, Sack JT, Vladimir Yarov-Yarovoy V (2015) Understanding the State Dependence of Voltage Sensor Toxin Action on Voltage Gated Sodium Channels. Biophys. J. 108 (Issue 2), 574a.
  28. Nguyen H, Wulff H, Yarov-Yarovoy V (2015) Validation of KCa3.1 Channel Nifedipine Interaction Site Predicted By Rosetta Modeling Method. Biophys. J. 108 (Issue 2), 582a-583a.
  29. Wulff H and Yarov-Yarovoy V (2015) Small Molecule Modulation of Voltage-Gated Ion Channels. Biophys. J. 108 (Issue 2), 177a.
  30. Yang F, Xiao X, Cheng W, Yang W, Yarov-Yarovoy V, Zheng J (2015) Molecular Mechanism of TRPV1 Activation by Capsaicin. Biophys. J. 108 (Issue 2), 124a.
  31. Brown BM, Coleman N, Yarov-Yarovoy V, Wulff H (2015) Positive KCa Channel Gating Modulators With Selectivity For KCa3.1. Biophys. J. 108 (Issue 2), 20a.
  32. Zamanian M, Bae C, Gupta K, Milescu M, Krepkiy D, Tilley D, Sack J, Yarov-Yarovoy V, Kim J, Swartz K (2015) Tarantula Toxins Use Common Surfaces For Interacting With Kv And Asic Ion Channels. Biophys. J. 108 (Issue 2), 82a.
  33. Nguyen PT, Sack JT, Allen TW, Yarov-Yarovoy V (2014) Structural Modeling of Toxin Interactions with the Human Voltage-Gated Sodium Channel Pore. Biophys. J. 106 (Issue 2), 130a.
  34. Tuluc P, Yarov-Yarovoy V, Benedetti B, Flucher BE (2014) Residues Critical for Voltage-Sensor Transitions Determining Gating Properties of Cav1.1. Biophys. J. 106 (Issue 2), 136a.
  35. Yang F, Yarov-Yarovoy V, Zheng J (2014) A Structural Framework for the Polymodal Pain Sensor TRPV1. Biophys. J. 106 (Issue 2), 756a.
  36. Rafizadeh S, Zhang Z, Woltz RL, Kim HJ, Lu L, Tuteja D, Singapuri A, Bigdeli AAZ, Harchache SB, Knowlton AA, Yamoah EN, Yarov-Yarovoy V, and Chiamvimonvat N (2014) Functional Interaction with Filamin a Enhances Atrial-Specific Small Conductance Ca2+ Activated K+ Channel (SK2) Surface Membrane Expression. Biophys. J. 106 (Issue 2), 118a.
  37. Zamanian M, Bae C, Tilley D, Gupta K, Sack J, Yarov-Yarovoy V, Kim JII, Swartz K (2014) Common Interaction Surfaces for Tarantula Toxins Targeting Kv and ASIC Channels. Biophys. J. 106 (Issue 2), 737a-738a.
  38. Tilley DC, Kaakati R, Yarov-Yarovoy V, Sack JT (2014) Rosetta Structural Modeling of Tarantula Toxin Binding to Voltage Sensors. Biophys. J. 106 (Issue 2), 737a.
  39. Fomina A, Yarov-Yarovoy V (2014) Structural Modeling of Hexameric and Tetrameric Ion Conduction Pathways of Orai1 Channel. Biophys. J. 106 (Issue 2), 314a.
  40. Yarov-Yarovoy V, Wulff H (2014) Structural Modeling of KCa3.1 Channel Interaction with Small Molecules. Biophys. J. 106 (Issue 2), 542a.
  41. Jenkins DP, Wulff H, and Yarov-Yarovoy V (2013) Rosetta modeling of the inner KCa3.1 pore, a hotspot for small molecule modulation. Program No. 913. Experimental Biology Meeting, Boston, MA.
  42. Yuen GK, Mamikonian L, Li J, Yarov-Yarovoy V, Bossuyt J, Bers DM (2013) The PLM Homotetramer has a Structural Basis that Parallels that of PLB: the Leucine Zipper. Biophys. J. 104 (Issue 2), 407a.
  43. Yang F, Yarov-Yarovoy V, Zheng J (2013) Modeling Temperature-Dependent Ion Channel Protein Structural Changes with Rosetta. Biophys. J. 104 (Issue 2), 229a - 230a.
  44. Tilley DC, Eum KS, Cohen BE, Yarov-Yarovoy V, Sack JT (2013) Fluorescently Labeled Tarantula Toxin Reveals Voltage Dependent Adhesion to K+ Channels. 104 (Issue 2), 197a.
  45. Nguyen PT, Sack JT, Allen TW, Yarov-Yarovoy V (2013) Structural Modeling of the Human Nav1.7 Channel Pore. Biophys. J. 104 (Issue 2), 137a.
  46. Yarov-Yarovoy V(2012) Structural Modeling of a Human Voltage-Gated Sodium Channel. Biophys. J. 102 (Issue 3), 603a.
  47. DeCaen P, Yarov-Yarovoy V, Scheuer T, and Catterall WA (2011) Disulfide Locking Reveals Interaction of the Gating Charges with a Negative Charge in the S1 Segment During Activation of the NaChBac Voltage Sensor. Biophys. J. 100 (Issue 3), 422a.
  48. Wang J, Yarov-Yarovoy V, Kahn R, Gordon D, Gurevitz M, Scheuer T, and Catterall WA (2011) Molecular Determinants for Alpha-Scorpion Toxin Binding to the Resting State of a Voltage Sensor of Brain Sodium Channels. Biophys. J. 100 (Issue 3), 422a.
  49. Yarov-Yarovoy V, DeCaen P, Scheuer T, Baker D, and Catterall WA (2011) High-resolution structural modeling of voltage-dependent conformational changes in the voltage-sensor of NaChBac. Biophys. J. 100 (Issue 3), 422a.
  50. Khalili-Araghi F, Jogini V, Yarov-Yarovoy V, Tajkhorshid E, Roux B, and Schulten K (2010) Refinement and Validation of Atomic Models of the Kv1.2 Potassium Channel Through Molecular Dynamics and Gating Charge Calculations. Biophys. J. 98 (Issue 3), 520a-521a.
  51. DeCaen P, Yarov-Yarovoy V, Scheuer T, and Catterall WA (2010) Disulfide Locking Reveals a Closed State Interaction Within the Voltage Sensor of NaChBac. Biophys. J. 98 (Issue 3), 112a.
  52. Yarov-Yarovoy V, Dimaio F, Scheuer T, Baker D, and Catterall WA (2010) High-resolution structural modeling of ion channel pore-forming domains using Rosetta. Biophys. J. 98 (Issue 3), 117a.
  53. Khalili-Araghi F, Jogini V, Yarov-Yarovoy V, Tajkhorshid E, Roux B, and Schulten K (2009) Molecular Dynamics Simulation of the Kv1.2 Potassium Channel. Biophys. J. 96 (Issue 3), 191a-192a.
  54. Yarov-Yarovoy V, DeCaen P, Scheuer T, and Catterall WA (2009) Structural Modeling of Intermediate States of the Gating Pore of NaChBac. Biophys. J. 96, 253.
  55. Yarov-Yarovoy V and Catterall WA (2008) Structural Model of the Voltage-Dependent Gating of NaChBac. Biophys. J. 94, 617.
  56. Yarov-Yarovoy V and Baker D (2006) Progress in de novo Prediction of Membrane Protein Structures Using Rosetta. Protein Sci. 15 (Suppl. 1), 359.
  57. Yarov-Yarovoy V, Schonbrun J, and Baker D (2005) De novo Prediction of Membrane Protein Structures Using Rosetta. Protein Sci. 14 (Suppl. 1), 592.
  58. Yarov-Yarovoy V, Cestèle S, Scheuer T, Baker D, and Catterall WA (2005) Structural Model of Beta-Scorpion Toxin Binding to Voltage-Gated Sodium Channels. Biophys. J. 88, 479.
  59. Yarov-Yarovoy V, Schonbrun J, Scheuer T, Catterall WA, and Baker D (2004) Ab Initio Ion Channel Structure Prediction Using ROSETTA. Biophys. J. 86, 609.
  60. Zhao Y, Yarov-Yarovoy V, Scheuer T, and Catterall WA (2003) The Gating Hinge of a Voltage-Gated Bacterial Sodium Channel. Program No. 164.10. Washington D.C.: Society for Neuroscience.
  61. Yarov-Yarovoy V, Brown J, Sharp E, Scheuer T, and Catterall WA (2000) Amino Acids in Transmembrane Segment IIIS6 of the Sodium Channel a Subunit form part of the Receptor for Lamotrigine and Etidocaine. Biophys. J., 78, 501.
  62. Yarov-Yarovoy V, Brown J, Sharp E, Catterall WA, and Scheuer T (2000) Amino Acids in Transmembrane Segment IIIS6 of the Voltage-dependent Sodium Channel a Subunit are Important for Normal Coupling of Activation to Inactivation. Biophys. J., 78, 500.
  63. Paucek P, BajgarR, Yarov-Yarovoy V, and Garkid KD (1999) Regulatory Sites of MitoKATP are on MitoSUR. Biophys. J., 76, A328.
  64. Yarov-Yarovoy V, Paucek P, and Garkid KD (1998) Photolabeling Cardiac Sarcolemmal Membrane Proteins with an 125I‑Labeled Glyburide Analog. Biophys. J., 74, A208.
  65. Paucek P, Garkid KD, Yarov-Yarovoy V, Murray HN, Darbenzio RB, D'Alonzo AJ, Lodge NJ, Smith MA, and Grover GJ (1997) Cardioprotective Effect of Diazoxide and its Interaction with Mitochondrial KATP: Possible Mechanism of Cardioprotection. J. Mol. Cell. Cardiol., 29, A199.
  66. Paucek P, Yarov-Yarovoy V, and Garkid KD (1997) Sulfonylurea Receptor of the Mitochondrial KATP Channel. Biophys. J., 72, A39.
  67. Garkid KD, Jaburek M, Yarov-Yarovoy V, and Paucek P (1997) Sulfonylurea Receptor ‑ K+ Channel Coupling in the Mitochondrial KATP Channel. Biophys. J., 72, A39.
  68. Garkid KD, Paucek P, and Yarov-Yarovoy V (1996) Regulation of the Mitochondrial KATP Channel by Palmitoyl CoA, Adenine and Guanine Nucleotides, and K+ Channel Openers. Biophys. J., 70, A311.
  69. Paucek P, Schindler PA, Yarov-Yarovoy V and Garkid KD (1996) Regulation of Partially Purified KATP Channel from Cardiac Sarcolemma by Nucleotides and K+ Channel Openers. Biophys. J., 70, A311.
  70. Garkid KD, Yarov-Yarovoy V, and Paucek P (1995) Orientation of the Native KATP Channel in the Inner Mitochondrial Membrane and in Liposomes Following Reconstitution. International Business Communication USA: Potassium Channel Modulators, Conference, Washington D.C.
  71. Paucek P, Schindler PA, Yarov-Yarovoy V, and Garkid KD (1995) Physiological and Pharmacological Regulation of the Mitochondrial KATP Channel. International Business Communication USA: Potassium Channel Modulators, Conference, Washington D.C.
  72. Paucek P, Yarov-Yarovoy V, Sun X, and Garkid KD (1995) Physiological and Pharmacological Activators of the Mitochondrial KATP Channel. Biophys. J., 68, A145.
  73. Mironova GM, Paucek P, Kolomytkyn OV, SkargaYY, Yarov-Yarovoy V, and Garlid KD (1994) Properties of the Mitochondrial ATP‑ dependent Potassium Channel Reconstituted into Lipid Bilayers. EBEC Short Reports, 94.

Bibliography

Stewart RG, Marquis MJ, Jo S, Ferns M, Sack JT. KvS regulatory subunits confer drug resistance to Kv2 channels. bioRxiv. (2024) doi: 10.1101/2024.01.31.578214.

Ferns M, van der List D, Vierra NC, Lacey T, Murray K, Kirmiz M, Stewart RG, Sack JT, Trimmer JS. Electrically silent KvS subunits associate with native Kv2 channels in brain and impact diverse properties of channel function. bioRxiv. (2024) doi: 10.1101/2024.01.25.577135.

Stewart RG, Camacena M, Copits BA, Sack JT. Distinct cellular expression and subcellular localization of Kv2 voltage-gated K(+) channel subtypes in dorsal root ganglion neurons conserved between mice and humans. Journal of Comparative Neurology. 532:e25575 (2024) doi: 10.1002/cne.25575.

Emigh Cortez AM, DeMarco KR, Furutani K, Bekker S, Sack JT, Wulff H, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural modeling of hERG channel-drug interactions using Rosetta. Frontiers in Pharmacology. 14:1244166 (2023) doi: 10.3389/fphar.2023.1244166.

Kimball IH, Nguyen PT, Olivera BM, Sack JT, Yarov-Yarovoy V. Molecular determinants of μ-conotoxin KIIIA interaction with the human voltage-gated sodium channel Na(V)1.7. Frontiers in Pharmacology 14:1156855 (2023) doi: 10.3389/fphar.2023.1156855.

Nguyen PT, Nguyen HM, Wagner KM, Stewart RG, Singh V, Thapa P, Chen YJ, Lillya MW, Ton AT, Kondo R, Ghetti A, Pennington MW, Hammock B, Griffith TN, Sack JT, Wulff H, Yarov-Yarovoy V. Computational design of peptides to target Na(V)1.7 channel with high potency and selectivity for the treatment of pain. Elife. 11 (2022) doi: 10.7554/eLife.81727. PubMed PMID: 36576241; PubMed Central PMCID: PMC9831606.

Maly J, Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural modeling of the hERG potassium channel and associated drug interactions. Frontiers in Pharmacology. 13:966463 (2022) doi: 10.3389/fphar.2022.966463.

Furutani K, Kawano R, Ichiwara M, Adachi R, Clancy CE, Sack JT, Kita S. Pore opening, not voltage sensor movement, underpins the voltage-dependence of facilitation by a hERG blocker. Molecular Pharmacology. 102:223-33 (2022) doi: 10.1124/molpharm.122.000569.

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Thapa P, Stewart R, Sepela RJ, Vivas O, Parajuli LK, Lillya M, Fletcher-Taylor S, Cohen BE, Zito K, Sack JT. EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues. Journal of General Physiology 153:e202012858 (2021) doi: 10.1085/jgp.202012858.

Stewart R, Cohen BE, Sack JT. Fluorescent toxins as ion channel activity sensors. Methods in Enzymology 653:295-318. (2021) doi: 10.1016/bs.mie.2021.02.014.

Fletcher-Taylor S, Thapa P, Sepela RJ, Kaakati R, Yarov-Yarovoy V, Sack JT, Cohen BE. Distinguishing Potassium Channel Resting State Conformations in Live Cells with Environment-Sensitive Fluorescence. ACS Chemical Neuroscience 11:2316-2326 (2020) doi: 10.1021/acschemneuro.0c00276

Tilley DC, Angueyra JM, Eum KS, Kim H, Chao LH, Peng AW, Sack JT. The tarantula toxin GxTx detains K+ channel gating charges in their resting conformation. Journal of General Physiology 151:292-315 (2019) doi:10.1085/jgp.201812213

Furutani K, Tsumoto K, Chen IS, Handa K, Yamakawa Y, Sack JT, Kurachi Y. Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations. Journal of General Physiology 151:214-230 (2019) doi:10.1085/jgp.201812192

Mann VR, Powers AS, Tilley DC, Sack JT, Cohen BE. Azide-Alkyne Click Conjugation on Quantum Dots by Selective Copper Coordination. ACS Nano 12, 4469-4477 (2018)

Kirmiz M, Palacio S, Thapa P, King AN, Sack JT, Trimmer JS. Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels. Molecular Biology of the Cell 29: 2410-2432 (2018)

Dockendorff C, Gandhi DM, Kimball IH, Eum KS, Rusinova R, Ingolfsson HI, Kapoor R, Peyear T, Dodge MW, Martin SF, Aldrich RW, Andersen OS, Sack JT. Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels. Biochemistry 57:2733-2743 (2018)

Sepela RJ, Sack JT. Taming unruly chloride channel inhibitors with rational design. Proceedings of the National Academy of Sciences of the United States of America 115:5311-5313 (2018)

Sack JT. The envenomation of general physiology throughout the last century. Journal of General Physiology 149:975-983 (2017)

Thiffault I, Speca DJ, Austin DC, Cobb MM, Eum KS, Safina NP, Grote L, Farrow EG, Miller N, Soden S, Kingsmore SF, Trimmer JS, Saunders CJ, Sack JT. A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization. Journal of General Physiology 146:399-410 (2015)

Sack JT, Tilley DC. What keeps Kv channels small? The molecular physiology of modesty. Journal of General Physiology 146:123-7 (2015)

Cobb MM, Austin DC, Sack JT, Trimmer JS. Cell Cycle-dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells. Journal of Biological Chemistry 290:29189-29201 (2015)

Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers D., Na+ Channel Function, Regulation, Structure, Trafficking and Sequestration. Journal of Physiology 593:1347-60 (2015)

Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Yarov-Yarovoy V, Kim JI, Swartz KJ. Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels. eLife, 4:e06774 (2015)

Sack JT, Eum KS. Ion channel Inhibitors. Handbook of Ion Channels. CRC Press, eds J. Zheng & M. C. Trudeau. Ch. 14, 189-197 (2015)

Tilley D, Eum KS, Fletcher-Taylor S, Austin DA, Dupre C, Patron L, Garcia R, Lam K, Yarov-Yarovoy V, Cohen BE, Sack JT. Chemoselective tarantula toxins report activation of wild-type ion channels in live cells. Proceedings of the National Academy of Sciences of the United States of America 111: E4789–E4796 (2014)

Ingólfsson HI, Thakur P, Herold KF, Maretzky T, Hall K, Zwama M, Yilmaz D, Hemmings HC, Blobel C, Koçer A, Sack JT, Andersen OS. Phytochemicals perturb membranes and promiscuously alter protein function. ACS Chemical Biology 9:1788-98 (2014)

Speca DJ, Ogata G, Mandikian D, Wiler SW, Eum K, Wenzel HJ, Doisy ET, Matt L, Campi KL, Golub MS, Nerbonne JM, Hell JW, Trainor BC, Sack JT, Schwartzkroin PA, Trimmer JS. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability. Genes, Brain and Behavior 13:394-408 (2014)

Sack JT, Stephanopoulos N, Austin DC, Francis MB, Trimmer JS. Antibody-guided photoablation of voltage-gated potassium currents. Journal of General Physiology 142:315-324 (2013)

Mandikian D, Cerda O, Sack JT, Trimmer JS. A SUMO-Phospho tag team for wrestling with potassium channel gating. Journal of General Physiology 137:435-439 (2011)

Al-Sabi A, Shamotienko O, Ní Dhochartaigh S, Muniyappa N, LeBerre M, Shaban H, Wang J, Sack JT, Dolly JO. Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium. Journal of General Physiology 136: 273-282 (2010)

Sack JT, Shamotienko O, Dolly JO. How to validate a heteromeric ion channel drug target: Assessing Proper Expression of Concatenated Subunits. Journal of General Physiology 131:415-20 (2008)

Sokolov MV, Shamotienko O, Dhochartaigh SN, Sack JT, Dolly JO. Concatemers of brain Kv1 channel alpha subunits that give similar K(+) currents yield pharmacologically distinguishable heteromers. Neuropharmacology 53:272-82 (2007)

Sack JT, Aldrich RW. Binding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel's activation pathway. Journal of General Physiology 128:119-32 (2006)

Sack JT, Aldrich RW, Gilly WF. A gastropod toxin selectively slows early transitions in the Shaker K channel's activation pathway. Journal of General Physiology 123:685-96 (2004)

Kelley WP, Wolters AM, Sack JT, Jockusch RA, Jurchen JC, Williams ER, Sweedler JV, Gilly WF. Characterization of a novel gastropod toxin (6-bromo-2-mercaptotryptamine) that inhibits shaker K channel activity. Journal of Biological Chemistry 278:34934-42 (2003)

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