Assistant Project Scientist

Recruitment Period

Open Date: January 7, 2025

Next Review Date: February 4, 2025 - Apply by February 4, 2025 (11:59 p.m.) to be considered in the first round of applicants. All applicants received will be released to the Search Committee the following day. More review dates will continue to be added if the position is not filled.

Description:
The Department of Physiology and Membrane Biology at the University of California, Davis, School of Medicine, seeks to hire one, full time Assistant Project Scientist in the Beleford Lab. The Assistant Project Scientist will perform research functions in vascular biology and human genetics.

The Project Scientist makes significant and creative contributions to a research or creative project in their academic discipline. The appointee possesses the subject matter expertise and the creative energy necessary to function at a high level of competence. The appointee will participate in activities to increase, improve, or upgrade competency in vascular biology and human genetics. Appointees with Project Scientist series may engage in University and public service. They do not have teaching responsibilities. Although the Project Scientist is expected to work independently under the general guidance of an academic member with an independent research program (i.e., Professor, Professional Researcher, etc.), they are not required to develop an independent research program or reputation. The Project Scientist will carry out research or creative programs with supervision by an individual in an academic title that carries with it automatic Principal status. The Project Scientist does not usually serve as a Principal Investigator but may do so by exception.

The incumbent will work under the supervision of Daniah Beleford and work cooperatively and collegially in a diverse environment.

Major Responsibilities

1. RESEARCH (90% EFFORT)
   Research Activity (70%)
   This position requires creative contributions to and collaborative development of an active research program investigating topics relevant to the research area of vascular biology and human genetics methods and applications. Topics include subcellular fractionation, co-immunoprecipitation, proximity ligation assay, and site-directed mutagenesis in order to identify specific protein binding partners and amino acid residues that facilitate direct binding to other proteins in endothelial cells. They will provide assistance with generating and maintaining patient-derived fibroblast and induced pluripotent stem cell-derived endothelial cell lines. They will also assist with mouse studies and with maintaining mouse colonies. Finally, the APS will contribute to mentoring and training the lab’s undergraduate, graduate, and junior specialist learners. They will provide input to data interpretation and conduct tracking, optimization of data acquisition and processing, data handling and analysis, and consulting with physician scientists on human application research.
   
   The appointee will help to determine research goals in consultation with the Principal Investigator. The Project Scientist will design specific projects, including the selection of appropriate methods and techniques.
   
   In some cases, the appointee may supervise students or technicians regarding the technical aspects of the research, including methods development, trouble-shooting problems, interpreting results and planning follow-up experiments. The appointee collaborates with scientific colleagues in multi-disciplinary projects that include components falling within the appointee’s area of expertise.
   
   Publication (10%)
   The appointee will publish research in peer-reviewed journals either independently or in collaboration with the PI or other members of the research team.
   
   Grant Acquisition (10%)
   The appointee will assist in writing proposals for funding from federal and state agencies and other funding organizations. The appointee will prepare and assist in the preparation of reports as required by granting agencies and prepare modifications of budgets and other grant components as needed.
2. PROFESSIONAL COMPETENCE AND ACTIVITY (5% EFFORT)
   The candidate will participate in professional societies and conferences appropriate to their specific field of vascular biology and human genetics and will serve as a reviewer of research proposals, and scientific publications as appropriate.
   
   The candidate will attend seminars to present research results and may give oral presentations to public and professional interest groups. When appropriate, the candidate may coordinate and/or give presentations at seminars and laboratory meeting.
3. UNIVERSITY AND PUBLIC SERVICE (5% EFFORT)
   The appointee may undertake administrative tasks relevant to the smooth running of the laboratory enterprise as appropriate.

BASIC QUALIFICATIONS:

• Ph.D. or equivalent in Biomedical Sciences, Biochemistry, Molecular Biology, Cell Biology, Genomics, or Developmental Biology
• At least 4 years of experience in molecular and cell biology post terminal degree.
• Prior experience in mouse genetics, rodent handling, tissue culture, bioinformatics
• Evidence of academic accomplishment such as peer-reviewed publications and/or conference presentations.

PREFERRED QUALIFICATIONS:

• Proficient with specific technology or procedures such as basic molecular biology (PCR, cloning, plasmid prep, DNA and protein electrophoresis, etc.) and cell biology (tissue culture, transfection, etc.)
• Training in genomics and bioinformatics is preferred
• Training in molecular biology and cell biology preferred
• Experience with rodent handling preferred

TO APPLY:
To apply, please go to the following link: JPF06894 . This position will remain open until filled.

Qualified applicants should submit:

• CV with a complete list of publications
• Statement of research
• Contact information for 3-5 references

Junior Specialist Position

Recruitment Period

Open Date: October 17, 2024

Next Review Date: November 17, 2024 - Apply by November 17, 2024 (11:59 p.m.) to be considered in the first round of applicants. All applicants received will be released to the Search Committee the following day. More review dates will continue to be added if the position is not filled.

Final Review Date: June 30, 2025 - Applications will continue to be accepted through this date, but those received after the initial review date will only be considered if the position has not yet been filled.

Description:

The Department of Physiology and Membrane Biology at the University of California, Davis, School of Medicine, seeks to hire one employee as a Junior Specialist in the Beleford lab . This position will be involved in interdisciplinary studies focusing on questions in vascular biology and molecular genetic causes of arterial, venous, and lymphatic malformations.

Major Responsibilities and Designated Areas of Expertise

The Junior Specialist has the general duties of working closely with the Principal Investigator (PI) in the planning and execution of a research projects. The junior specialist may assist in data collection, entry and quality control, study design and implementation, literature reviews and data analysis for preparation of manuscripts or conference presentations, and writing conference abstracts and manuscripts (e.g., methods and results sections, table, and figure generation) for a particular project.

The incumbent will work under the supervision of Daniah Beleford and work cooperatively and collegially in a diverse environment.

Successful candidates are expected to participate in three major categories of activities listed below:

1. RESEARCH (90% EFFORT)
   The incumbent will collaborate with other research personnel affiliated with research activities involving investigating the molecular genetic origin of vascular disease. The Junior Specialist will manage, maintain, and inventory transgenic mouse colonies including tagging, tail-snipping, and genotyping mice, crossbreeding to generate specific genetic lines, intraperitoneal and intragastric injections, and assisting with harvesting mouse tissues for analysis. Other responsibilities include establishing endothelial cell lines from harvested mouse and human tissues, inventorying frozen stocks, and maintaining these lines in culture. Molecular techniques that may be carried out by the Junior Specialist include immunocyto- and immunohistochemistry, fluorescent imaging and light microscopy, RNAScope, immunoprecipitation, Western analysis, and proximity ligation assay. The Junior Specialist is encouraged to lead at least one, possibly two independent research projects with input from the PI and opportunities for publication. The specialist is also expected to contribute to writing and reviewing manuscripts in preparation. The ideal candidate will be motivated, detail-oriented, have strong analytical and time-management skills, and be capable of working collaboratively with others.
2. PROFESSIONAL COMPETENCE AND ACTIVITY (5% EFFORT)
   The appointee is encouraged to attend department, and technical society talks and journal clubs relevant to vascular biology. The appointee may also attend up to 2 local or national conferences relevant to vascular biology. The PI will assist with applications for funding to attend conferences as needed.
3. UNIVERSITY AND PUBLIC SERVICE (5% EFFORT)
   The incumbent may be expected to provide mentorship to undergraduate research assistants that rotate through the lab. They will be expected to participate and contribute to laboratory and group meetings, and other activities, as applicable.

This recruitment is conducted at the junior rank. The resulting hire will be at the junior rank regardless of the proposed appointee’s qualifications.

A reasonable estimate for this position is $53,100 at Step 1 or $56,600 at Step 2.

Basic Qualifications

• Bachelor’s Degree in Biology, Genetics, or related field. Degree must be awarded before start date.
• Minimum one year of laboratory research experience.
• Experience with basic tissue culture, PCR, DNA gel

Preferred Qualifications

• Experience with rodent
• Prior experience with basic laboratory molecular
• Prior experience with mentoring early

TO APPLY:

To apply, please go to the following link: JPF06779. This position will remain open until filled.

Qualified applicants should submit

• Cover letter detailing their qualification for this position
• CV
• Unofficial Transcripts
• Contact information for 3 references