Publications
2023
Han JS, Fishman-Williams E, Decker SC, Hino K, Reyes RV, Brown NL, Simó S, Torre A. "Notch directs telencephalic development and controls neocortical neuron fate determination by regulating microRNA levels". Development. 2023 Jun 1;150(11):dev201408. doi: 10.1242/dev.201408. Epub 2023 Jun 5. PMID: 37272771; PMCID: PMC10309580.
Bosze B, Suarez-Navarro J, Cajias I, Brzezinski Iv JA, Brown NL. "Notch pathway mutants do not equivalently perturb mouse embryonic retinal development". PLoS Genet. 2023 Sep 26;19(9):e1010928. doi: 10.1371/journal.pgen.1010928. PMID: 37751417; PMCID: PMC10522021.
2021
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Bosze, B., J. Suarez-Navarro, A. Soofi, J.D. Lauderdale, G.R. Dressler and N.L. Brown. Multiple Roles for Pax2 in the embryonic mouse eye. Developmental Biology: Jan 8;S0012-1606(21)00005-1. DOI: 10.1016/j.ydbio.2020.12.020 PMID 33428890. |
2020
Joel B. Miesfeld, Noor M. Ghiasvand, Brennan Marsh-Armstrong, Nicholas Marsh-Armstrong, Eric B. Miller, Pengfei Zhang, Suman K. Manna, Robert J. Zawadzki, Nadean L. Brown, Tom Glaser. The Atoh7 remote enhancer provides transcriptional robustness during retinal ganglion cell development. Proceedings of the National Academy of Sciences Sep 2020, 117 (35) 21690-21700; DOI: 10.1073/pnas.2006888117.
Bösze, B., Hufnagel, R.B. and N.L. Brown (2020). Specification of Retinal Cell Types in Patterning and Cell Type Specification in the Developing CNS and PNS: Comprehensive Developmental Neuroscience Second Edition; Editors, John Rubenstein and Pasko Rakic. pp. 481-504.
Bosze B, Moon MS, Kageyama R, Brown NL. Simultaneous Requirements for Hes1 in Retinal Neurogenesis and Optic Cup-Stalk Boundary Maintenance. J Neurosci. 2020 Feb 12;40(7):1501-1513. doi: 10.1523/JNEUROSCI.2327-19.2020. Epub 2020 Jan 16. PubMed PMID: 31949107.
*Selected for recognition in the JNeurosci Annual Spotlight. YouTube.
2019
Miesfeld, J.B. and N.L. Brown (2019). Eye Organogenesis: A hierarchical view of ocular development, Current Topics in Developmental Biology: Organ Development, Editor Deneen Wellik. Vol 132: 351-393.
P.T. Lam, S.L. Padula, T.V. Hoang, J.E. Poth, L. Liu, C. Liang, A.S. LeFever, L.M. Wallace, R. Ashery-Padan, P.K. Riggs, J.E. Shields, O. Shaham, S. Rowan, N.L. Brown, T. Glaser, M.L. Robinson. (2019) Considerations for the Use of Cre Recombinase for Conditional Gene Deletion in the Mouse Lens. Human Genomics:13:10.
Azimi, M. and N.L. Brown (2019) Jagged1 protein processing in the developing mammalian lens. Biology Open: 8: bio041095.
2018
Baker, N.E. and N.L. Brown (2018) All in the Family: Proneural bHLH genes and neuronal diversity. Development: 145: dev159426.
Maurer, K.A., A.M. Kowalchuk, F. Shoja-Taheri and N.L. Brown (2018) Integral bHLH Factor Regulation of Cell Cycle Exit and RGC Differentiation. Developmental Dynamics: 247:965–975, 2018 Epub ahead of print: doi: 10.1002/dvdy.24638 |
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Kowalchuk, A.M., K.A. Maurer, F. Shoja-Taheri, N.L. Brown (2018) Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis. Developmental Biology: Jul 24 pii: S0012-1606(17)30608-5 Epub ahead of print.
Miesfeld, J.B*., M-S. Moon*, A.N. Riesenberg, A. Reyer, R.A. Kovall and N.L. Brown (2018) Rbpj is a direct regulator of Atoh7 transcription in the embryonic mouse retina. Scientific Reports:Jul 5;8(1):10195
(*Co-first authors)
Azimi, M., T.T. Le and N.L. Brown (2018) Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens. Differentiation: Jul 25;102:40-52 Epub ahead of print.
2017
Miesfeld, J.B., T. Glaser and N.L. Brown, The dynamics of native Atoh7 protein expression during mouse retinal histogenesis, revealed with a new antibody, Gene Expression Patterns: 2017 Dec 7;27:114-121.
Riesenberg, A.N., K.W. Conley, T.T. Le and N.L. Brown, Separate and coincident expression of Hes1 and Hes5 in the developing mouse eye, Developmental Dynamics: Epub 2Aug17; Vol 247: 212-221 (Jan 2018).
Zhang, Q., J. Zogozewski, S. Cheng, R. Dixit, S. Zhang, J. de Melo, X. Mu, W.H. Klein, N.L. Brown, J.T. Wigle, C. Schuurmans, D.D. Eisenstat. Regulation of Brn3b by DLX1 and DLX2 is required for retinal ganglion cell differentiation in the vertebrate retina. Development 144: 1698-1711.
2016
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Riesenberg, A.N. And N.L. Brown (2016) Cell autonomous and nonautonomous requirements for Delltalike1 during early mouse retinal neurogenesis. Developmental Dynamics 245: 631-40. |
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2014
Maurer, K.A, Riesenberg, A.N. and N.L. Brown (2014) Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina. Development: 141: 3243-3254.
2013
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Hufnagel, R.B. and N.L. Brown (2013). Specification of Retinal Cell Types in Patterning and Cell Type Specification in the Developing CNS and PNS: Comprehensive Developmental Neuroscience; Editors, John Rubenstein and Pasko Rakic. pp 519-537. |
Hufnagel, R.B.*, A.N. Riesenberg,* J.A. Brzezinski IV, M. Quinn, T. Glaser and N.L. Brown. (2013)
2012
Saravanamuthu, S.S., T.T. Le, C.Y. Gao, C. Liu, C. Radu, P. Pandiyan, J. Zhang, P.S. Zelenka and N.L. Brown. (2012) Conditional ablation of the Notch2 receptor in the ocular lens. Developmental Biology 362: 219-29.
Le, T.T., K. Conley, T.J. Mead, S. Rowan, K.E. Yutzey and N.L. Brown. (2012) Requirements for Jag1-Rbpj mediated Notch signaling during mouse lens vesicle development. Developmental Dynamics 241: 493-504
2011
Charlton-Perkins, M., N.L. Brown, and T.A. Cook. (2011) The Lens in Focus: A Comparison of Lens Development in Drosophila and Vertebrates. Molecular Genetics & Genomics 286: 189-213.
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(Click on the images to enlarge)
2010
Prasov, L, Brown, NL and Glaser, T. (2010) A critical analysis of Atoh7 (Math5) splicing in the developing mouse retina. PLoS One. Aug 5(8):e12315.
Macgregor S, Hewitt AW, Hysi PG, Ruddle JB,Medland SE, Henders AK, Gordon SD, Andrew T, McEvoy B, Sanfilippo PG, Carbonaro F, Tah V, Li YJ, Bennett SL, Craig JE, Montgomery GW, Tran-Viet KN, Brown NL, Spector TD, Martin NG, Young TL, Hammond CJ, Mackey DA. (2010) Genome-wide association identifies ATOH7 as a major gene determining human optic nerve size. Human Molecular Genetics. 340: 490-503.
Hufnagel RB, Le TT, Riesenberg AL, Brown NL. (2010) Neurog2 controls the leading edge of neurogenesis in the mammalian retina. Developmental Biology 340: 490-503.
2009
Riesenberg AN, Liu Z, Kopan R, Brown NL. (2009) Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. Journal of Neuroscience 29: 12865-77.
Riesenberg AN, Le TT, Willardsen MI, Blackburn DC, Vetter ML, Brown NL. (2009) Pax6 regulation of Math5 during mouse retinal neurogenesis. Genesis 47:175-187.
Le TT, Conley K, Brown NL. (2009) Jagged1 is necessary for normal mouse lens development. Developmental Biology 328:118-126.
Willardsen MI, Suli A, Pan Y, Marsh-Armstrong N, El-Hodiri H, Chen CB, Moore KB, Brown NL, Vetter ML. (2009) Temporal regulation of Ath5 gene expression during eye development. Developmental Biology 326:471-481.
Fuhrmann S, Riesenberg AN, Mathiesen AM, Brown EC, Vetter ML, Brown NL. (2009) Characterization of a transient TCF/LEF-responsive progenitor population in the embryonic mouse retina. Invest Ophth Vis Sci. 50:432-440.
2008
Rowan S, Conley K, Le TT, Donner AL, Maas RL, Brown, NL. (2008) Notch signaling is required for mouse lens growth and differentiation. Developmental Biology. 321:111-122.
Blackburn DC*, Conley K*, Plachetzki D, Kempler K, Battelle BA, Brown NL. (2008) Isolation and expression of Pax6 and atonal homologues in the American Horseshoe Crab, Limulus polyphemus. Developmental Dynamics 237:2209-2219.
2007
Hufnagel RB, Riesenberg AN, Saul SM, Brown NL. (2007) Conserved regulation between Math5 and Math1 as revealed by Math5-GFP transgenes. Molecular and Cellular Neuroscience 36:435-488.