Biennial UC Davis Cardiovascular Symposium


Heart diseases including arrhythmias and heart failure (HF) are the No.1 killer in the developed world for both men and women. To develop better and more effective therapies to combat heart diseases, it is critically important for scientists and physicians to gain more accurate and deeper understanding of the mechanisms that underlie heart diseases. In recent decades, researchers have made important conceptual advances and accumulated a large body of experimental cardiac functional data at molecular, cellular and whole organ levels. However, there is a critical need to integrate these data into mechanistic and quantitative models to under­stand emergent properties of complex biological system—such as arrhythmias—that are often counterintuitive (due to non-linear dynamics interactions). Quantitative model predictions test the depth of our knowledge, guide novel experimental tests, and provide strategies for rational design of novel therapeutic approaches.

In order to facilitate and foster interdisciplinary research on heart disease mechanisms, we bring together leading experimentalists and mathematical modelers in this series of interactive conferences. The emphases are on summarizing current state of research in the focus area, identifying consensus & controversy (where more investigation is needed), giving experimentalists access to modeling tools and modelers a deeper under­standing of the data that must drive their models, so the participants will gain multi-scale integrative and comprehensive perspectives. Each conference in this series presents an important research area that can benefit greatly from combining experimental studies with mathematical modeling and integrating with other areas. Together, these conferences will cover topics that are essential for understanding heart disease mechanisms at multi-scale levels from molecular to cellular to the whole heart and to patients.