To advance research frontiers by combining experimental and modeling approaches, we bring together leading experimentalists and mathematical modelers in this series of interactive conferences. The emphases are on summarizing current state of research in the focus area, identifying consensus and controversy (where more investigation is needed), giving experimentalists access to modeling tools and modelers a deeper under¬standing of the data that must drive their models. We have planned the following focus points for this series of symposia; each focuses on an important research area that can benefit greatly from combining experimental studies with mathematical modeling. Together, these conferences cover the topics that are essential for understanding heart disease mechanisms at multi-scale levels from molecular to cellular and to the whole heart. Below is our plan for this conference series under the unifying theme of Systems Approach to Understanding Cardiac E-C coupling and Arrhythmias.


UC Davis Cardiovascular Symposium 2010

System’s approach to understanding E-C coupling and arrhythmia mechanisms

The 1st symposium brought together experimentalists and modelers to gain an overview of the state of research in cardiac E-C coupling with respect to arrhythmias, to examine the current understanding at multiple levels from molecular to cellular and to the whole heart, and set the stage for subsequent meetings.
(Click for the Symposium 2010 program)


UC Davis Cardiovascular Symposium 2012

Ca2+ currents and SR Ca2+ release

The 2nd symposium focuses on Ca2+ channels and ryanodine receptors, their interaction in cardiac E-C coupling, and their connection to Ca2+-induced arrhythmias and HF.
(Click for internal white papers, Click for the Symposium 2012 program)


UC Davis Cardiovascular Symposium 2014

Na+ channel and Na+ transport

The 3rd symposium focuses on Na+ channels, Na/K-ATPase, Na/Ca exchanger, and their interaction in setting Na+ and Ca2+ homeostasis, and in connection to arrhythmias and HF.
(Click for published white papers, Click for the Symposium 2014 program)


UC Davis Cardiovascular Symposium 2016

K+ channels and regulation

Topics will comprise fundamental gating properties, including consensus on measured properties, computational representations, generation of arrhythmias, and therapeutics.
(Click for published papers, Click for the Symposium 2016 program)


UC Davis Cardiovascular Symposium 2018

Contractile system and dysfunction in HF and arrhythmias

Focus on the link between contractile system defects and HF and arrhythmias, computational modeling of the contractile, Ca2+ signaling, and electrical systems.
(Click for the Symposium 2018 program)


UC Davis Cardiovascular Symposium 2020

Integrating dynamic systems of cardiac E-C coupling

Focus on integration of the contributions of the electrical, Ca2+ signaling, and contractile systems (and their coupling) to cardiac function and diseases.
(Click for the Symposium 2020 program)


The journey continues…