Recent Publications
2018
Sato, D., R.E. Dixon, L.F. Santana, and M.F. Navedo (2018). A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics. PLoS Comput Biol. 14:e1005906.
2017
Vivas, O., C.M. Moreno, L.F. Santana, and B. Hille (2017). Proximal clustering between BK and CaV1.3 channels promotes functional coupling and BK channel activation at low voltage. eLife. 6.
Tajada, S., C.M. Moreno, S. O'Dwyer, S. Woods, D. Sato, M.F. Navedo, and L.F. Santana (2017). Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCalpha in arterial myocytes. J Gen Physiol. 149:639-659.
Nieves-Cintron, M., A.U. Syed, O.R. Buonarati, R.R. Rigor, M.A. Nystoriak, D. Ghosh, K.C. Sasse, S.M. Ward, L.F. Santana, J.W. Hell, and M.F. Navedo (2017). Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes. Sci Rep. 7:14058.
Li, L., J. Li, B.M. Drum, Y. Chen, H. Yin, X. Guo, S.W. Luckey, M.L. Gilbert, G.S. McKnight, J.D. Scott, L.F. Santana, and Q. Liu (2017). Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve. Cardiovascular research. 113:147-159.
Ghosh, D., A.U. Syed, M.P. Prada, M.A. Nystoriak, L.F. Santana, M. Nieves-Cintron, and M.F. Navedo (2017). Calcium Channels in Vascular Smooth Muscle. Adv Pharmacol. 78:49-87.
Gentil, B.J., E. O'Ferrall, C. Chalk, L.F. Santana, H.D. Durham, and R. Massie (2017). A New Mutation in FIG4 Causes a Severe Form of CMT4J Involving TRPV4 in the Pathogenic Cascade. J Neuropathol Exp Neurol. 76:789-799.
2016
Nieves-Cintron, M., D. Hirenallur-Shanthappa, P.J. Nygren, S.A. Hinke, M.L. Dell'Acqua, L.K. Langeberg, M. Navedo, L.F. Santana, and J.D. Scott (2016). AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K+ currents in ventricular myocytes following myocardial infarction. Cell Signal. 28:733-740.
Moreno, C. M., R. E. Dixon, S. Tajada, C. Yuan, X. Opitz-Araya, M. D. Binder and L. F. Santana (2016). Ca2+ entry into neurons is facilitated by cooperative gating of clustered Ca1.3 channels. Elife 5.
Drum, B. M., C. Yuan, L. Li, Q. Liu, L. Wordeman and L. F. Santana (2016). Oxidative stress decreases microtubule growth and stability in ventricular myocytes. Journal of Molecular and Cellular Cardiology 93: 32-43.
2015
Drum, B. M. and L. F. Santana (2015). The long and winding road home: How junctin and triadin find their way to the junctional SR. Journal of Molecular and Cellular Cardiology 81: 15-17.
Dixon, R. E., C. M. Moreno, C. Yuan, X. Opitz-Araya, M. D. Binder, M. F. Navedo and L. F. Santana (2015). Graded Ca2+/calmodulin-dependent coupling of voltage-gated CaV1.2 channels. Elife 4.
2014
Zhang, C., B. Chen, A. Guo, Y. Zhu, J. D. Miller, S. Gao, C. Yuan, W. Kutschke, K. Zimmerman, R. M. Weiss, X. H. Wehrens, J. Hong, F. L. Johnson, L. F. Santana, M. E. Anderson and L. S. Song (2014). Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure. Circulation 129(17): 1742-1750.
Sonkusare, S. K., T. Dalsgaard, A. D. Bonev, D. C. Hill-Eubanks, M. I. Kotlikoff, J. D. Scott, L. F. Santana and M. T. Nelson (2014). AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension. Science Signaling 7(333): ra66.
Nystoriak, M. A., M. Nieves-Cintron, P. J. Nygren, S. A. Hinke, C. B. Nichols, C. Y. Chen, J. L. Puglisi, L. T. Izu, D. M. Bers, M. L. Dell'acqua, J. D. Scott, L. F. Santana and M. F. Navedo (2014). AKAP150 Contributes to Enhanced Vascular Tone by Facilitating Large-Conductance Ca2+-Activated K+ Channel Remodeling in Hyperglycemia and Diabetes Mellitus. Circulation Research 114(4): 607-615.
Mercado, J., R. Baylie, M. F. Navedo, C. Yuan, J. D. Scott, M. T. Nelson, J. E. Brayden and L. F. Santana (2014). Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle. Journal of General Physiology 143(5): 559-575.
Guan, X., D. L. Mack, C. M. Moreno, J. L. Strande, J. Mathieu, Y. Shi, C. D. Markert, Z. Wang, G. Liu, M. W. Lawlor, E. C. Moorefield, T. N. Jones, J. A. Fugate, M. E. Furth, C. E. Murry, H. Ruohola-Baker, Y. Zhang, L. F. Santana and M. K. Childers (2014). Dystrophin-deficient cardiomyocytes derived from human urine: New biologic reagents for drug discovery. Stem Cell Research 12(2): 467-480.
Drum, B. M., R. E. Dixon, C. Yuan, E. P. Cheng and L. F. Santana (2014). Cellular mechanisms of ventricular arrhythmias in a mouse model of Timothy syndrome (long QT syndrome 8). Journal of Molecular and Cellular Cardiology 66: 63-71.