The Chien Laboratory

Publications

Complete List of Published Work: My Bibliography | Google Scholar

Selected:

  1. De Souza C, Madden J, Koestler DC, Minn D, Montoya DJ, Minn K, Raetz AG, Zhu Z, Xiao WW, Tahmassebi N, Reddy H, Nelson N, Karnezis AN, Chien J. Effect of the p53 P72R Polymorphism on Mutant TP53 Allele Selection in Human Cancer. J Natl Cancer Inst. 2021 Feb 8;. doi: 10.1093/jnci/djab019. [Epub ahead of print] PubMed PMID: 33555293.
  2. Zhang W, Petegrosso R, Chang JW, Sun J, Yong J, Chien J, Kuang R. A large-scale comparative study of isoform expressions measured on four platforms. BMC Genomics. 2020 Mar 30;21(1):272. doi: 10.1186/s12864-020-6643-8. PubMed PMID: 32228441; PubMed Central PMCID: PMC7106849.
  3. Pan-cancer analysis of whole genomes. Nature. 2020 Feb;578(7793):82-93. doi: 10.1038/s41586-020-1969-6. Epub 2020 Feb 5. PubMed PMID: 32025007; PubMed Central PMCID: PMC7025898.
  4. Fang P, De Souza C, Minn K, Chien J. Genome-scale CRISPR knockout screen identifies TIGAR as a modifier of PARP inhibitor sensitivity. Commun Biol. 2019 Sep 9;2:335. doi: 10.1038/s42003-019-0580-6. eCollection 2019.PMID:31508509
  5. Fang P, Madden JA, Neums L, Moulder RK, Forrest ML, Chien J. Olaparib-induced Adaptive Response Is Disrupted by FOXM1 Targeting that Enhances Sensitivity to PARP Inhibition. Mol Cancer Res. 2018 Jun;16(6):961-973. PubMed PMID: 29545475.
  6. Bastola P, Wang F, Schaich MA, Gan T, Freudenthal BD, Chou TF, Chien J. Specific mutations in the D1-D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors. Cell Death Discov. 2017;3:17065. PubMed PMID: 29367883; PubMed Central PMCID: PMC5672561.
  7. Bastola P, Neums L, Schoenen FJ, Chien J. VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase-mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal. Mol Oncol. 2016 Dec;10(10):1559-1574. PubMed PMID: 27729194; PubMed Central PMCID: PMC5423134.
  8. Zhang X, Cheng L, Minn K, Madan R, Godwin AK, Shridhar V, Chien J. Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells. Oncotarget. 2014 Nov 30;5(22):11365-80. PubMed PMID: 25426548; PubMed Central PMCID: PMC4294351.
  9. Neums L, Suenaga S, Beyerlein P, Anders S, Koestler D, Mariani A, Chien J. VaDiR: an integrated approach to Variant Detection in RNA. Gigascience. 2018 Feb 1;7(2)PubMed PMID: 29267927; PubMed Central PMCID: PMC5827345.
  10. Meier R, Graw S, Beyerlein P, Koestler D, Molina JR, Chien J. digit-a tool for detection and identification of genomic interchromosomal translocations. Nucleic Acids Res. 2017 May 19;45(9):e72. PubMed PMID: 28132028; PubMed Central PMCID: PMC5435966.
  11. Munchel S, Hoang Y, Zhao Y, Cottrell J, Klotzle B, Godwin AK, Koestler D, Beyerlein P, Fan JB, Bibikova M, Chien J. Targeted or whole genome sequencing of formalin fixed tissue samples: potential applications in cancer genomics. Oncotarget. 2015 Sep 22;6(28):25943-61. PubMed PMID: 26305677; PubMed Central PMCID: PMC4694877.
  12. Graw S, Meier R, Minn K, Bloomer C, Godwin AK, Fridley B, Vlad A, Beyerlein P, Chien J. Robust gene expression and mutation analyses of RNA-sequencing of formalin-fixed diagnostic tumor samples. Sci Rep. 2015 Jul 23;5:12335. PubMed PMID: 26202458; PubMed Central PMCID: PMC4511951.
  13. Chien J, Sicotte H, Fan JB, Humphray S, Cunningham JM, Kalli KR, Oberg AL, Hart SN, Li Y, Davila JI, Baheti S, Wang C, Dietmann S, Atkinson EJ, Asmann YW, Bell DA, Ota T, Tarabishy Y, Kuang R, Bibikova M, Cheetham RK, Grocock RJ, Swisher EM, Peden J, Bentley D, Kocher JP, Kaufmann SH, Hartmann LC, Shridhar V, Goode EL. TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer. Nucleic Acids Res. 2015 Aug 18;43(14):6945-58. PubMed PMID: 25916844; PubMed Central PMCID: PMC4538798.
  14. Integrated genomic analyses of ovarian carcinoma. Nature. 2011 Jun 29;474(7353):609-15. PubMed PMID: 21720365; PubMed Central PMCID: PMC3163504.
  15. Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, Chen H, Zhao Y, Pearson E, Li X, Chien J, Dewan A, Harmon J, Bernstein PS, Shridhar V, Zabriskie NA, Hoh J, Howes K, Zhang K. A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science. 2006 Nov 10;314(5801):992-3. PubMed PMID: 17053109.
  16. Chien J, Aletti G, Baldi A, Catalano V, Muretto P, Keeney GL, Kalli KR, Staub J, Ehrmann M, Cliby WA, Lee YK, Bible KC, Hartmann LC, Kaufmann SH, Shridhar V. Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity. J Clin Invest. 2006 Jul;116(7):1994-2004. PubMed PMID: 16767218; PubMed Central PMCID: PMC1474818.
  17. Chien J, Narita K, Rattan R, Giri S, Shridhar R, Staub J, Beleford D, Lai J, Roberts LR, Molina J, Kaufmann SH, Prendergast GC, Shridhar V. A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation. Oncogene. 2008 Dec 11;27(58):7223-34. PubMed PMID: 18806825; PubMed Central PMCID: PMC2754286.
  18. Chien J, Staub J, Hu SI, Erickson-Johnson MR, Couch FJ, Smith DI, Crowl RM, Kaufmann SH, Shridhar V. A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer. Oncogene. 2004 Feb 26;23(8):1636-44. PubMed PMID: 14716297.
  19. Lai JP, Chien J, Strome SE, Staub J, Montoya DP, Greene EL, Smith DI, Roberts LR, Shridhar V. HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma. Oncogene. 2004 Feb 19;23(7):1439-47. PubMed PMID: 14973553.
  20. Kommoss S, Winterhoff B, Oberg AL, Konecny GE, Wang C, Riska SM, Fan JB, Maurer MJ, April C, Shridhar V, Kommoss F, du Bois A, Hilpert F, Mahner S, Baumann K, Schroeder W, Burges A, Canzler U, Chien J, Embleton AC, Parmar M, Kaplan R, Perren T, Hartmann LC, Goode EL, Dowdy SC, Pfisterer J. Bevacizumab May Differentially Improve Ovarian Cancer Outcome in Patients with Proliferative and Mesenchymal Molecular Subtypes. Clin Cancer Res. 2017 Jul 15;23(14):3794-3801. PubMed PMID: 28159814; PubMed Central PMCID: PMC5661884.
  21. Chien J, Ota T, Aletti G, Shridhar R, Boccellino M, Quagliuolo L, Baldi A, Shridhar V. Serine protease HtrA1 associates with microtubules and inhibits cell migration. Mol Cell Biol. 2009 Aug;29(15):4177-87. PubMed PMID: 19470753; PubMed Central PMCID: PMC2715801.